Gene description for BTG2
Gene name BTG family, member 2
Gene symbol BTG2
Other names/aliases PC3
TIS21
Species Homo sapiens
 Database cross references - BTG2
ExoCarta ExoCarta_7832
Vesiclepedia VP_7832
Entrez Gene 7832
HGNC 1131
MIM 601597
UniProt P78543  
 BTG2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for BTG2
Molecular Function
    transcription corepressor activity GO:0003714 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    DNA repair GO:0006281 TAS
    DNA damage response GO:0006974 IDA
    neuroblast proliferation GO:0007405 IEA
    negative regulation of neuroblast proliferation GO:0007406 IEA
    negative regulation of cell population proliferation GO:0008285 IBA
    negative regulation of cell population proliferation GO:0008285 IMP
    associative learning GO:0008306 IEA
    response to mechanical stimulus GO:0009612 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    negative regulation of translation GO:0017148 IDA
    dentate gyrus development GO:0021542 IEA
    central nervous system neuron development GO:0021954 IEA
    neuron projection development GO:0031175 IMP
    skeletal muscle cell differentiation GO:0035914 IEA
    response to peptide hormone GO:0043434 IEA
    negative regulation of neuron apoptotic process GO:0043524 IEA
    response to electrical stimulus GO:0051602 IEA
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 IDA
    cellular response to phorbol 13-acetate 12-myristate GO:1904628 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified BTG2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BTG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pick1  
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Two-hybrid Rattus norvegicus
2 CNOT7 29883
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 Cnot7  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
4 FBXL3  
Affinity Capture-Western Homo sapiens
5 CNOT6L 246175
Affinity Capture-MS Homo sapiens
6 FBXW2  
Affinity Capture-Western Homo sapiens
7 HOXB9  
Two-hybrid Homo sapiens
Far Western Homo sapiens
8 CUL1 8454
Affinity Capture-Western Homo sapiens
9 BTRC 8945
Affinity Capture-Western Homo sapiens
10 FBXW11  
Affinity Capture-Western Homo sapiens
11 SKP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 CNOT1 23019
Affinity Capture-MS Homo sapiens
13 PRMT1 3276
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 CNOT8  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
15 SRA1 10011
Far Western Homo sapiens
16 SKP1 6500
Affinity Capture-Western Homo sapiens
17 DDX58 23586
Affinity Capture-RNA Homo sapiens
18 HOXC8  
Far Western Homo sapiens
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