Gene description for CNOT6L
Gene name CCR4-NOT transcription complex, subunit 6-like
Gene symbol CNOT6L
Other names/aliases CCR4b
Species Homo sapiens
 Database cross references - CNOT6L
ExoCarta ExoCarta_246175
Vesiclepedia VP_246175
Entrez Gene 246175
HGNC 18042
UniProt Q96LI5  
 CNOT6L identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CNOT6L
Molecular Function
    metal ion binding GO:0046872 IEA
    poly(A)-specific ribonuclease activity GO:0004535 TAS
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of cell proliferation GO:0008284 IMP
    regulation of translation GO:0006417 IEA
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 TAS
    gene silencing by RNA GO:0031047 IEA
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    mRNA destabilization GO:0061157 IEA
    gene expression GO:0010467 TAS
    RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503 TAS
    positive regulation of cytoplasmic mRNA processing body assembly GO:0010606 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    CCR4-NOT complex GO:0030014 IDA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified CNOT6L in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CNOT6L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BTG2 7832
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CNOT6L is involved
PathwayEvidenceSource
Deadenylation of mRNA TAS Reactome





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