Gene description for Cnot3
Gene name CCR4-NOT transcription complex, subunit 3
Gene symbol Cnot3
Other names/aliases A930039N10Rik
Species Mus musculus
 Database cross references - Cnot3
ExoCarta ExoCarta_232791
Entrez Gene 232791
UniProt Q8K0V4  
 Cnot3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cnot3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    multicellular organismal development GO:0007275 IEA
    regulation of translation GO:0006417 IEA
    gene silencing by RNA GO:0031047 IEA
    transcription, DNA-templated GO:0006351 IEA
    regulation of stem cell maintenance GO:2000036 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    trophectodermal cell differentiation GO:0001829 IMP
Subcellular Localization
    CCR4-NOT complex GO:0030014 ISO
    cytoplasmic mRNA processing body GO:0000932 IDA
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Cnot3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cnot3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cnot3 is involved
PathwayEvidenceSource
Deadenylation of mRNA IEA Reactome





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