Gene description for CNOT3
Gene name CCR4-NOT transcription complex, subunit 3
Gene symbol CNOT3
Other names/aliases LENG2
NOT3
NOT3H
Species Homo sapiens
 Database cross references - CNOT3
ExoCarta ExoCarta_4849
Vesiclepedia VP_4849
Entrez Gene 4849
HGNC 7879
MIM 604910
UniProt O75175  
 CNOT3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CNOT3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 IBA
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 NAS
    trophectodermal cell differentiation GO:0001829 IEA
    regulation of DNA-templated transcription GO:0006355 IEA
    regulation of translation GO:0006417 IEA
    regulatory ncRNA-mediated gene silencing GO:0031047 IEA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    regulation of stem cell population maintenance GO:2000036 IBA
    regulation of stem cell population maintenance GO:2000036 IMP
Subcellular Localization
    P-body GO:0000932 IBA
    P-body GO:0000932 ISS
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
    CCR4-NOT complex GO:0030014 IDA
    CCR4-NOT complex GO:0030014 NAS
    CCR4-NOT core complex GO:0030015 IBA
 Experiment description of studies that identified CNOT3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CNOT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNOT7 29883
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 RPSAP58 388524
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 TEX13A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CCNH  
Affinity Capture-MS Homo sapiens
7 CNOT2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
8 RPA2 6118
Proximity Label-MS Homo sapiens
9 ABCF3 55324
Affinity Capture-MS Homo sapiens
10 CAND2 23066
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
11 C9orf78 51759
Affinity Capture-MS Homo sapiens
12 APEX1 328
Affinity Capture-RNA Homo sapiens
13 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RPS20 6224
Proximity Label-MS Homo sapiens
15 CNOT10 25904
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
16 DYRK1A 1859
Affinity Capture-MS Homo sapiens
17 RC3H1 149041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RC3H2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SNX27 81609
Affinity Capture-MS Homo sapiens
20 TOB2  
Affinity Capture-MS Homo sapiens
21 HSPA8 3312
Affinity Capture-MS Homo sapiens
22 CPEB1  
Proximity Label-MS Homo sapiens
23 BTG3  
Affinity Capture-MS Homo sapiens
24 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
25 CNOT11 55571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CAPZA1 829
Affinity Capture-MS Homo sapiens
27 FANCD2OS  
Affinity Capture-MS Homo sapiens
28 DRG1 4733
Affinity Capture-MS Homo sapiens
29 MEX3C 51320
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
30 TNKS1BP1 85456
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
31 CNOT4 4850
Co-fractionation Homo sapiens
32 CNOT1 23019
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
33 NTRK1 4914
Affinity Capture-MS Homo sapiens
34 GLI3 2737
Proximity Label-MS Homo sapiens
35 CNOT6L 246175
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
36 NCS1 23413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GPBP1L1  
Affinity Capture-MS Homo sapiens
38 MNAT1  
Affinity Capture-MS Homo sapiens
39 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
40 ID3  
Two-hybrid Homo sapiens
41 TMEM131  
Affinity Capture-MS Homo sapiens
42 NANOS3  
Affinity Capture-Western Homo sapiens
43 NANOS1 340719
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
44 NLK  
Affinity Capture-MS Homo sapiens
45 C16orf72 29035
Affinity Capture-MS Homo sapiens
46 MINK1 50488
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CIRBP 1153
Co-fractionation Homo sapiens
48 MMP7 4316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RNF219  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
50 CNOT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 XPO1 7514
Affinity Capture-MS Homo sapiens
52 BAG2 9532
Affinity Capture-MS Homo sapiens
53 RQCD1 9125
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
54 GADD45B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CTTN 2017
Affinity Capture-MS Homo sapiens
56 TSSC4  
Affinity Capture-MS Homo sapiens
57 TNRC6B  
Affinity Capture-Western Homo sapiens
58 Cnot3 232791
Affinity Capture-MS Mus musculus
59 RPA3 6119
Proximity Label-MS Homo sapiens
60 SCGN  
Affinity Capture-MS Homo sapiens
61 RIBC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 PIK3CA 5290
Affinity Capture-MS Homo sapiens
63 PABPN1L  
Affinity Capture-MS Homo sapiens
64 Rpl35 66489
Affinity Capture-MS Mus musculus
65 TOB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 FHL2 2274
Affinity Capture-MS Homo sapiens
67 HUWE1 10075
Affinity Capture-MS Homo sapiens
68 MAP2K2 5605
Affinity Capture-MS Homo sapiens
69 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
70 NANOS2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 SRRM1 10250
Affinity Capture-MS Homo sapiens
72 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
73 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 Tnks1bp1  
Affinity Capture-MS Mus musculus
75 TNRC6C  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 MAGEA9  
Affinity Capture-MS Homo sapiens
77 RAVER1 125950
Affinity Capture-MS Homo sapiens
78 CNOT8  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
79 GLI2  
Proximity Label-MS Homo sapiens
80 HNRNPLL 92906
Co-fractionation Homo sapiens
81 Rrbp1  
Affinity Capture-MS Mus musculus
82 Cnot2  
Affinity Capture-MS Mus musculus
83 SERBP1 26135
Proximity Label-MS Homo sapiens
84 KRAS 3845
Negative Genetic Homo sapiens
85 TNRC6A 27327
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
86 EP300 2033
Affinity Capture-MS Homo sapiens
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