Gene description for CNOT10
Gene name CCR4-NOT transcription complex, subunit 10
Gene symbol CNOT10
Other names/aliases -
Species Homo sapiens
 Database cross references - CNOT10
ExoCarta ExoCarta_25904
Vesiclepedia VP_25904
Entrez Gene 25904
HGNC 23817
UniProt Q9H9A5  
 CNOT10 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CNOT10
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 NAS
    mRNA catabolic process GO:0006402 IBA
    negative regulation of translation GO:0017148 IBA
    regulatory ncRNA-mediated gene silencing GO:0031047 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    CCR4-NOT complex GO:0030014 IBA
    CCR4-NOT complex GO:0030014 IDA
    CCR4-NOT complex GO:0030014 NAS
 Experiment description of studies that identified CNOT10 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CNOT10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNOT7 29883
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 POLR2C 5432
Proximity Label-MS Homo sapiens
3 KRT18 3875
Proximity Label-MS Homo sapiens
4 KLHL20  
Affinity Capture-MS Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 MINK1 50488
Affinity Capture-MS Homo sapiens
7 TEX13A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MAPRE1 22919
Affinity Capture-MS Homo sapiens
9 MMP7 4316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RNF219  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
11 SEPT10 151011
Proximity Label-MS Homo sapiens
12 TNKS1BP1 85456
Affinity Capture-MS Homo sapiens
13 CNOT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GADD45B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 C9orf78 51759
Affinity Capture-MS Homo sapiens
16 PTGES3 10728
Affinity Capture-MS Homo sapiens
17 RC3H2  
Affinity Capture-MS Homo sapiens
18 USP22 23326
Affinity Capture-MS Homo sapiens
19 CPEB1  
Proximity Label-MS Homo sapiens
20 EPAS1  
Affinity Capture-MS Homo sapiens
21 CTTN 2017
Affinity Capture-MS Homo sapiens
22 RQCD1 9125
Affinity Capture-MS Homo sapiens
23 BTG3  
Affinity Capture-MS Homo sapiens
24 LCK 3932
Proximity Label-MS Homo sapiens
25 RPL10 6134
Affinity Capture-MS Homo sapiens
26 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CNOT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 BRD2  
Affinity Capture-MS Homo sapiens
29 CAPZA1 829
Affinity Capture-MS Homo sapiens
30 DCTN2 10540
Proximity Label-MS Homo sapiens
31 FANCD2OS  
Affinity Capture-MS Homo sapiens
32 G3BP2 9908
Affinity Capture-MS Homo sapiens
33 METTL21B  
Affinity Capture-MS Homo sapiens
34 CNOT3 4849
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
35 MAGEA9  
Affinity Capture-MS Homo sapiens
36 PPL 5493
Co-fractionation Homo sapiens
37 MKI67  
Affinity Capture-MS Homo sapiens
38 LTB4R2  
Two-hybrid Homo sapiens
39 KRT38 8687
Affinity Capture-MS Homo sapiens
40 DUSP6 1848
Affinity Capture-MS Homo sapiens
41 SQSTM1 8878
Proximity Label-MS Homo sapiens
42 Cnot3 232791
Affinity Capture-MS Mus musculus
43 ANAPC2 29882
Proximity Label-MS Homo sapiens
44 CNOT4 4850
Co-fractionation Homo sapiens
45 PABPN1L  
Affinity Capture-MS Homo sapiens
46 TNRC6C  
Affinity Capture-MS Homo sapiens
47 PPP4R1L  
Affinity Capture-MS Homo sapiens
48 RAVER1 125950
Affinity Capture-MS Homo sapiens
49 CNOT11 55571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CDC16 8881
Affinity Capture-MS Homo sapiens
51 NANOS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CNOT1 23019
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
53 HECW2  
Affinity Capture-MS Homo sapiens
54 CNOT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 VCP 7415
Affinity Capture-MS Homo sapiens
56 PXN 5829
Proximity Label-MS Homo sapiens
57 SCGN  
Affinity Capture-MS Homo sapiens
58 RIBC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 NUP153 9972
Affinity Capture-MS Homo sapiens
60 CT55  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 RIT1 6016
Negative Genetic Homo sapiens
62 Cnot2  
Affinity Capture-MS Mus musculus
63 CNOT6L 246175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 RIPK1 8737
Affinity Capture-MS Homo sapiens
65 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 NPM1 4869
Affinity Capture-MS Homo sapiens
67 GPBP1L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 PPP6R1 22870
Proximity Label-MS Homo sapiens
69 TOB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 TNRC6A 27327
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
71 STAT1 6772
Co-fractionation Homo sapiens
72 KRT19 3880
Proximity Label-MS Homo sapiens
73 TMEM131  
Affinity Capture-MS Homo sapiens
74 RPA3 6119
Proximity Label-MS Homo sapiens
75 FHL2 2274
Affinity Capture-MS Homo sapiens
76 CHMP1B 57132
Two-hybrid Homo sapiens
77 STIL  
Proximity Label-MS Homo sapiens
78 RC3H1 149041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 NANOS1 340719
Affinity Capture-MS Homo sapiens
80 DYRK1A 1859
Affinity Capture-MS Homo sapiens
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