Gene description for CNOT11
Gene name CCR4-NOT transcription complex, subunit 11
Gene symbol CNOT11
Other names/aliases C2orf29
C40
Species Homo sapiens
 Database cross references - CNOT11
ExoCarta ExoCarta_55571
Entrez Gene 55571
HGNC 25217
UniProt Q9UKZ1  
 CNOT11 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CNOT11
Molecular Function
    protein binding GO:0005515 IPI
    molecular_function GO:0003674 ND
Biological Process
    cell proliferation GO:0008283 NAS
    gene expression GO:0010467 TAS
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 TAS
    gene silencing by RNA GO:0031047 IEA
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    regulation of translation GO:0006417 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    CCR4-NOT complex GO:0030014 IDA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified CNOT11 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CNOT11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CNOT11 is involved
PathwayEvidenceSource
Deadenylation of mRNA TAS Reactome





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