Gene description for TIMM10B
Gene name translocase of inner mitochondrial membrane 10 homolog B (yeast)
Gene symbol TIMM10B
Other names/aliases FXC1
TIM10B
Tim9b
Species Homo sapiens
 Database cross references - TIMM10B
ExoCarta ExoCarta_26515
Vesiclepedia VP_26515
Entrez Gene 26515
HGNC 4022
MIM 607388
UniProt Q9Y5J6  
 TIMM10B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TIMM10B
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    unfolded protein binding GO:0051082 ISS
Biological Process
    cell-matrix adhesion GO:0007160 TAS
    protein insertion into mitochondrial inner membrane GO:0045039 ISS
    protein insertion into mitochondrial inner membrane GO:0045039 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial intermembrane space GO:0005758 TAS
    mitochondrial intermembrane space protein transporter complex GO:0042719 IBA
    mitochondrial intermembrane space protein transporter complex GO:0042719 IDA
    mitochondrial intermembrane space protein transporter complex GO:0042719 IPI
    TIM22 mitochondrial import inner membrane insertion complex GO:0042721 IDA
 Experiment description of studies that identified TIMM10B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TIMM10B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HPSE2  
Affinity Capture-MS Homo sapiens
2 PNOC  
Affinity Capture-MS Homo sapiens
3 EIF3F 8665
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 MSI2 124540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PRDM1  
Affinity Capture-MS Homo sapiens
6 KLHL38  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
8 TIMM10  
Affinity Capture-MS Homo sapiens
9 CNOT11 55571
Affinity Capture-MS Homo sapiens
10 FAM120AOS  
Affinity Capture-MS Homo sapiens
11 AGK 55750
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PNKD  
Affinity Capture-MS Homo sapiens
13 SUGP2  
Co-fractionation Homo sapiens
14 MEIS2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 TTLL4  
Affinity Capture-MS Homo sapiens
16 CYP2A13  
Affinity Capture-MS Homo sapiens
17 MRPL51 51258
Affinity Capture-MS Homo sapiens
18 IGF2R 3482
Co-fractionation Homo sapiens
19 HGS 9146
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 STX7 8417
Co-fractionation Homo sapiens
21 ADCYAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PRKCE 5581
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TIMM10B is involved
PathwayEvidenceSource
Mitochondrial protein import TAS Reactome
Protein localization TAS Reactome





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