Gene description for MRPL51
Gene name mitochondrial ribosomal protein L51
Gene symbol MRPL51
Other names/aliases CDA09
HSPC241
MRP64
bMRP64
Species Homo sapiens
 Database cross references - MRPL51
ExoCarta ExoCarta_51258
Entrez Gene 51258
HGNC 14044
MIM 611855
UniProt Q4U2R6  
 MRPL51 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MRPL51
Molecular Function
    structural constituent of ribosome GO:0003735 ISS
    protein binding GO:0005515 IPI
Biological Process
    mitochondrial translational initiation GO:0070124 TAS
    translation GO:0006412 ISS
    organelle organization GO:0006996 TAS
    mitochondrial translational elongation GO:0070125 TAS
    mitochondrial translation GO:0032543 TAS
    mitochondrial translational termination GO:0070126 TAS
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial ribosome GO:0005761 IDA
    mitochondrial large ribosomal subunit GO:0005762 ISS
 Experiment description of studies that identified MRPL51 in exosomes
1
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MRPL51
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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