Gene description for MRPL11
Gene name mitochondrial ribosomal protein L11
Gene symbol MRPL11
Other names/aliases CGI-113
L11MT
MRP-L11
Species Homo sapiens
 Database cross references - MRPL11
ExoCarta ExoCarta_65003
Vesiclepedia VP_65003
Entrez Gene 65003
HGNC 14042
MIM 611826
UniProt Q9Y3B7  
 MRPL11 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL11
Molecular Function
    RNA binding GO:0003723 HDA
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 NAS
    protein binding GO:0005515 IPI
    large ribosomal subunit rRNA binding GO:0070180 IBA
Biological Process
    translation GO:0006412 IBA
    translation GO:0006412 NAS
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial ribosome GO:0005761 NAS
    mitochondrial large ribosomal subunit GO:0005762 IBA
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL11 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MRPL54  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
2 MTG2  
Proximity Label-MS Homo sapiens
3 MRPL24  
Proximity Label-MS Homo sapiens
4 MRPL27 51264
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
5 SOX2  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MRPS18C  
Proximity Label-MS Homo sapiens
7 IARS2 55699
Proximity Label-MS Homo sapiens
8 Trp53bp1  
Affinity Capture-MS Mus musculus
9 ETFA 2108
Proximity Label-MS Homo sapiens
10 POLRMT 5442
Proximity Label-MS Homo sapiens
11 ZBTB14  
Two-hybrid Homo sapiens
12 NDUFAB1 4706
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
13 SLC30A9 10463
Proximity Label-MS Homo sapiens
14 BCS1L 617
Proximity Label-MS Homo sapiens
15 PREPL 9581
Proximity Label-MS Homo sapiens
16 VWA8 23078
Proximity Label-MS Homo sapiens
17 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
18 RPL19 6143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RBMX 27316
Proximity Label-MS Homo sapiens
20 MPV17 4358
Co-fractionation Homo sapiens
21 CMAS 55907
Proximity Label-MS Homo sapiens
22 TLX3  
Proximity Label-MS Homo sapiens
23 TMEM177  
Co-fractionation Homo sapiens
24 SRSF3 6428
Affinity Capture-MS Homo sapiens
25 YBX2 51087
Affinity Capture-MS Homo sapiens
26 NT5DC2 64943
Proximity Label-MS Homo sapiens
27 TUFM 7284
Co-fractionation Homo sapiens
28 LHX1  
Proximity Label-MS Homo sapiens
29 MRPS6  
Proximity Label-MS Homo sapiens
30 THG1L 54974
Proximity Label-MS Homo sapiens
31 DBT 1629
Proximity Label-MS Homo sapiens
32 MRPL41 64975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
33 Cep131  
Affinity Capture-MS Mus musculus
34 MRPL14 64928
Proximity Label-MS Homo sapiens
35 EARS2  
Proximity Label-MS Homo sapiens
36 WBSCR16  
Proximity Label-MS Homo sapiens
37 HADHA 3030
Proximity Label-MS Homo sapiens
38 ABT1 29777
Affinity Capture-MS Homo sapiens
39 MRPL10 124995
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
40 MTIF2 4528
Proximity Label-MS Homo sapiens
41 YBX1 4904
Affinity Capture-MS Homo sapiens
42 SRSF4 6429
Affinity Capture-MS Homo sapiens
43 CRYAB 1410
Two-hybrid Homo sapiens
44 MRPL16  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
45 CUL3 8452
Affinity Capture-MS Homo sapiens
46 EBNA1BP2 10969
Proximity Label-MS Homo sapiens
47 FKBP8 23770
Co-fractionation Homo sapiens
48 GADD45GIP1  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
49 HMBOX1  
Two-hybrid Homo sapiens
50 VARS2  
Proximity Label-MS Homo sapiens
51 MTG1  
Proximity Label-MS Homo sapiens
52 DLST 1743
Proximity Label-MS Homo sapiens
53 DDX54 79039
Proximity Label-MS Homo sapiens
54 DLAT 1737
Proximity Label-MS Homo sapiens
55 CAMK2G 818
Two-hybrid Homo sapiens
56 MRPL18 29074
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
57 STX2 2054
Two-hybrid Homo sapiens
58 HSPE1 3336
Proximity Label-MS Homo sapiens
59 GLS 2744
Proximity Label-MS Homo sapiens
60 RPS27A 6233
Proximity Label-MS Homo sapiens
61 ATP5J 522
Proximity Label-MS Homo sapiens
62 CLPX 10845
Proximity Label-MS Homo sapiens
63 RRS1 23212
Proximity Label-MS Homo sapiens
64 ETV3  
Proximity Label-MS Homo sapiens
65 LARS2 23395
Proximity Label-MS Homo sapiens
66 COX5A 9377
Proximity Label-MS Homo sapiens
67 NUDT19 390916
Proximity Label-MS Homo sapiens
68 SSBP1 6742
Co-fractionation Homo sapiens
69 NIPSNAP1 8508
Proximity Label-MS Homo sapiens
70 NME4 4833
Proximity Label-MS Homo sapiens
71 ALYREF 10189
Proximity Label-MS Homo sapiens
72 HNRNPL 3191
Proximity Label-MS Homo sapiens
73 JAKMIP2  
Two-hybrid Homo sapiens
74 ARHGAP20  
Affinity Capture-MS Homo sapiens
75 FECH 2235
Proximity Label-MS Homo sapiens
76 MRPS16  
Proximity Label-MS Homo sapiens
77 CAMK2D 817
Two-hybrid Homo sapiens
78 MRPL55  
Proximity Label-MS Homo sapiens
79 CSRP3  
Affinity Capture-MS Homo sapiens
80 POLG  
Proximity Label-MS Homo sapiens
81 MRPL28 10573
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
82 SP7  
Proximity Label-MS Homo sapiens
83 LUC7L 55692
Proximity Label-MS Homo sapiens
84 NDUFS6  
Proximity Label-MS Homo sapiens
85 SLC16A9  
Two-hybrid Homo sapiens
86 AFG3L2 10939
Proximity Label-MS Homo sapiens
87 H1FNT  
Affinity Capture-MS Homo sapiens
88 MRPL48  
Proximity Label-MS Homo sapiens
89 ELF1 1997
Proximity Label-MS Homo sapiens
90 KLF9 687
Proximity Label-MS Homo sapiens
91 GTPBP10  
Proximity Label-MS Homo sapiens
92 BTF3 689
Affinity Capture-MS Homo sapiens
93 ANAPC15  
Affinity Capture-MS Homo sapiens
94 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
95 CAND1 55832
Affinity Capture-MS Homo sapiens
96 MRPL49 740
Proximity Label-MS Homo sapiens
97 NDUFS2 4720
Proximity Label-MS Homo sapiens
98 JAKMIP1 152789
Two-hybrid Homo sapiens
99 HINT2 84681
Proximity Label-MS Homo sapiens
100 HARS2 23438
Proximity Label-MS Homo sapiens
101 MRPS23 51649
Proximity Label-MS Homo sapiens
102 NDUFA5 4698
Proximity Label-MS Homo sapiens
103 NPM1 4869
Cross-Linking-MS (XL-MS) Homo sapiens
104 MALSU1  
Affinity Capture-MS Homo sapiens
105 ERAL1  
Proximity Label-MS Homo sapiens
106 PHB 5245
Proximity Label-MS Homo sapiens
107 NDUFV3 4731
Proximity Label-MS Homo sapiens
108 MRPS7 51081
Proximity Label-MS Homo sapiens
109 LHX4  
Proximity Label-MS Homo sapiens
110 CUL1 8454
Affinity Capture-MS Homo sapiens
111 TACO1  
Proximity Label-MS Homo sapiens
112 FASTKD2  
Proximity Label-MS Homo sapiens
113 PDPR 55066
Proximity Label-MS Homo sapiens
114 Mad2l1bp  
Affinity Capture-MS Mus musculus
115 NNT 23530
Proximity Label-MS Homo sapiens
116 CCDC172  
Two-hybrid Homo sapiens
117 MRPL45 84311
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
118 ZNF526  
Two-hybrid Homo sapiens
119 ATPAF1  
Proximity Label-MS Homo sapiens
120 AGTRAP 57085
Two-hybrid Homo sapiens
121 MRPL51 51258
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
122 PDHX 8050
Proximity Label-MS Homo sapiens
123 POLDIP2 26073
Proximity Label-MS Homo sapiens
124 MRPL3  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
125 KLF12  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 CYLD  
Affinity Capture-MS Homo sapiens
127 ABCB7 22
Proximity Label-MS Homo sapiens
128 NDUFV1 4723
Proximity Label-MS Homo sapiens
129 MRPL44  
Proximity Label-MS Homo sapiens
130 ACOT1 641371
Proximity Label-MS Homo sapiens
131 IBA57  
Proximity Label-MS Homo sapiens
132 MRPS35 60488
Proximity Label-MS Homo sapiens
133 RC3H2  
Affinity Capture-MS Homo sapiens
134 MRPS11  
Proximity Label-MS Homo sapiens
135 RTN4IP1  
Proximity Label-MS Homo sapiens
136 MRPL9 65005
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
137 ATP5F1 515
Proximity Label-MS Homo sapiens
138 EGFR 1956
Negative Genetic Homo sapiens
139 DHTKD1 55526
Proximity Label-MS Homo sapiens
140 MYC  
Affinity Capture-MS Homo sapiens
141 ATP5B 506
Proximity Label-MS Homo sapiens
142 ACAD9 28976
Proximity Label-MS Homo sapiens
143 DDRGK1 65992
Affinity Capture-MS Homo sapiens
144 MRPS17 51373
Proximity Label-MS Homo sapiens
145 NDUFV2 4729
Proximity Label-MS Homo sapiens
146 PPIF 10105
Proximity Label-MS Homo sapiens
147 RPL13 6137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 CLPP 8192
Proximity Label-MS Homo sapiens
149 CS 1431
Proximity Label-MS Homo sapiens
150 C17orf80 55028
Proximity Label-MS Homo sapiens
151 ILF3 3609
Co-fractionation Homo sapiens
152 HOMEZ  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
153 PDCL 5082
Two-hybrid Homo sapiens
154 TRMT61B  
Proximity Label-MS Homo sapiens
155 MRPS15  
Proximity Label-MS Homo sapiens
156 PNMA1 9240
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
157 SHMT2 6472
Proximity Label-MS Homo sapiens
158 RPS5 6193
Co-fractionation Homo sapiens
159 ME2 4200
Proximity Label-MS Homo sapiens
160 GFM1 85476
Proximity Label-MS Homo sapiens
161 TEFM  
Proximity Label-MS Homo sapiens
162 QRSL1  
Proximity Label-MS Homo sapiens
163 MRPS9 64965
Proximity Label-MS Homo sapiens
164 MRPS27 23107
Proximity Label-MS Homo sapiens
165 SLIRP 81892
Proximity Label-MS Homo sapiens
166 NDUFS1 4719
Proximity Label-MS Homo sapiens
167 MRPL30  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
168 MRPL17  
Proximity Label-MS Homo sapiens
169 ANGEL2 90806
Proximity Label-MS Homo sapiens
170 NOA1  
Proximity Label-MS Homo sapiens
171 PYCR1 5831
Proximity Label-MS Homo sapiens
172 GATB  
Proximity Label-MS Homo sapiens
173 CARS2 79587
Proximity Label-MS Homo sapiens
174 LRPPRC 10128
Proximity Label-MS Homo sapiens
175 HNRNPAB 3182
Proximity Label-MS Homo sapiens
176 NDUFS3 4722
Proximity Label-MS Homo sapiens
177 SUPV3L1 6832
Proximity Label-MS Homo sapiens
178 KLF6  
Proximity Label-MS Homo sapiens
179 ETV4  
Proximity Label-MS Homo sapiens
180 ATP5J2-PTCD1  
Proximity Label-MS Homo sapiens
181 CAMK2B 816
Two-hybrid Homo sapiens
182 MRPL39 54148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
183 NDUFAF1  
Proximity Label-MS Homo sapiens
184 TFCP2 7024
Two-hybrid Homo sapiens
185 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
186 MTERF3  
Proximity Label-MS Homo sapiens
187 LIN28A  
Affinity Capture-MS Homo sapiens
188 MDH2 4191
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
189 GOLGA6L9  
Two-hybrid Homo sapiens
190 ALAS1  
Proximity Label-MS Homo sapiens
191 MRPS25 64432
Proximity Label-MS Homo sapiens
192 DLD 1738
Co-fractionation Homo sapiens
193 FOXA1  
Affinity Capture-MS Homo sapiens
194 THEM4  
Proximity Label-MS Homo sapiens
195 SAMM50 25813
Co-fractionation Homo sapiens
196 CENPV 201161
Proximity Label-MS Homo sapiens
197 PAM16  
Proximity Label-MS Homo sapiens
198 KIAA0391  
Proximity Label-MS Homo sapiens
199 MTPAP 55149
Proximity Label-MS Homo sapiens
200 MRPL2 51069
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
201 HNRNPDL 9987
Proximity Label-MS Homo sapiens
202 PAIP2B  
Affinity Capture-MS Homo sapiens
203 ACAT1 38
Proximity Label-MS Homo sapiens
204 ZBTB2 57621
Two-hybrid Homo sapiens
205 MRPL40 64976
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
206 POLR3A 11128
Co-fractionation Homo sapiens
207 TRMT10C 54931
Proximity Label-MS Homo sapiens
208 PNPT1 87178
Proximity Label-MS Homo sapiens
209 CDK5RAP1  
Proximity Label-MS Homo sapiens
210 MRPS14  
Proximity Label-MS Homo sapiens
211 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
212 DHX30 22907
Proximity Label-MS Homo sapiens
213 HNRNPUL1 11100
Proximity Label-MS Homo sapiens
214 THAP1  
Two-hybrid Homo sapiens
215 MRPS28  
Proximity Label-MS Homo sapiens
216 MRPL19 9801
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
217 KRT40  
Two-hybrid Homo sapiens
218 MRPS36 92259
Proximity Label-MS Homo sapiens
219 RNF2  
Affinity Capture-MS Homo sapiens
220 MRPL38  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
221 RBMS2 5939
Affinity Capture-MS Homo sapiens
222 DDX50 79009
Proximity Label-MS Homo sapiens
223 RPL37 6167
Affinity Capture-MS Homo sapiens
224 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
225 PHB2 11331
Proximity Label-MS Homo sapiens
226 RBFA  
Proximity Label-MS Homo sapiens
227 PDK3 5165
Proximity Label-MS Homo sapiens
228 NDUFAF2  
Proximity Label-MS Homo sapiens
229 RPL6 6128
Affinity Capture-MS Homo sapiens
230 UQCC1 55245
Proximity Label-MS Homo sapiens
231 GTPBP6