Gene description for PDPR
Gene name pyruvate dehydrogenase phosphatase regulatory subunit
Gene symbol PDPR
Other names/aliases PDP3
Species Homo sapiens
 Database cross references - PDPR
ExoCarta ExoCarta_55066
Entrez Gene 55066
HGNC 30264
UniProt Q8NCN5  
 PDPR identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PDPR
Molecular Function
    oxidoreductase activity GO:0016491 IEA
Biological Process
    pyruvate metabolic process GO:0006090 TAS
    oxidation-reduction process GO:0055114 IEA
    small molecule metabolic process GO:0044281 TAS
    cellular metabolic process GO:0044237 TAS
    regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010510 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified PDPR in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PDPR
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PDPR is involved
PathwayEvidenceSource
Regulation of pyruvate dehydrogenase (PDH) complex TAS Reactome





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