Gene description for TSFM
Gene name Ts translation elongation factor, mitochondrial
Gene symbol TSFM
Other names/aliases EFTS
EFTSMT
Species Homo sapiens
 Database cross references - TSFM
ExoCarta ExoCarta_10102
Entrez Gene 10102
HGNC 12367
MIM 604723
UniProt P43897  
 TSFM identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TSFM
Molecular Function
    translation elongation factor activity GO:0003746 IBA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    mitochondrial translation GO:0032543 TAS
    translational elongation GO:0006414 TAS
    mitochondrial translational elongation GO:0070125 TAS
    organelle organization GO:0006996 TAS
    regulation of DNA-templated transcription, elongation GO:0032784 TAS
Subcellular Localization
    mitochondrion GO:0005739 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    mitochondrial matrix GO:0005759 IBA
 Experiment description of studies that identified TSFM in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TSFM
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TSFM is involved
PathwayEvidenceSource
Mitochondrial translation elongation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here