Gene description for CPLX2
Gene name complexin 2
Gene symbol CPLX2
Other names/aliases 921-L
CPX-2
CPX2
Hfb1
Species Homo sapiens
 Database cross references - CPLX2
ExoCarta ExoCarta_10814
Entrez Gene 10814
HGNC 2310
MIM 605033
UniProt Q6PUV4  
 CPLX2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for CPLX2
Molecular Function
    syntaxin-1 binding GO:0017075 IEA
    calcium-dependent protein binding GO:0048306 IEA
Biological Process
    regulation of exocytosis GO:0017157 TAS
    positive regulation of synaptic plasticity GO:0031915 ISS
    nervous system development GO:0007399 IEA
    vesicle docking involved in exocytosis GO:0006904 TAS
    cell differentiation GO:0030154 IEA
    synaptic vesicle exocytosis GO:0016079 IEA
    mast cell degranulation GO:0043303 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex GO:0070033 IEA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex GO:0070554 TAS
    synapse GO:0045202 IEA
    mast cell granule GO:0042629 IEA
 Experiment description of studies that identified CPLX2 in exosomes
1
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CPLX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX1A 6804
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CPLX2 is involved
No pathways found





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