Gene description for FAM21A
Gene name family with sequence similarity 21, member A
Gene symbol FAM21A
Other names/aliases FAM21B
bA56A21.1
bA98I6.1
Species Homo sapiens
 Database cross references - FAM21A
ExoCarta ExoCarta_387680
Entrez Gene 387680
HGNC 23416
UniProt Q641Q2  
 FAM21A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FAM21A
Molecular Function
    lipid binding GO:0008289 IEA
Biological Process
    retrograde transport, endosome to Golgi GO:0042147 ISS
    protein transport GO:0015031 IEA
Subcellular Localization
    WASH complex GO:0071203 ISS
    early endosome membrane GO:0031901 IEA
    early endosome GO:0005769 ISS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified FAM21A in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FAM21A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FAM21A is involved
No pathways found





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