Gene description for Capza1
Gene name capping protein (actin filament) muscle Z-line, alpha 1
Gene symbol Capza1
Other names/aliases CAPZ
CAZ1
Cappa1
Species Mus musculus
 Database cross references - Capza1
ExoCarta ExoCarta_12340
Entrez Gene 12340
UniProt P47753  
 Capza1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Capza1
Molecular Function
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 IDA
    actin binding GO:0003779 IEA
Biological Process
    barbed-end actin filament capping GO:0051016 IDA
    actin filament capping GO:0051693 IEA
Subcellular Localization
    cell-cell junction GO:0005911 IDA
    extracellular exosome GO:0070062 ISO
    brush border GO:0005903 IDA
    F-actin capping protein complex GO:0008290 IDA
    membrane GO:0016020 IDA
    WASH complex GO:0071203 ISO
    cytoplasm GO:0005737 IEA
    cortical cytoskeleton GO:0030863 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Capza1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Capza1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Capza1 is involved
No pathways found





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