Gene description for Sgta
Gene name small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
Gene symbol Sgta
Other names/aliases 5330427H01Rik
AI194281
D10Ertd190e
Sgt
Stg
Species Mus musculus
 Database cross references - Sgta
ExoCarta ExoCarta_52551
Vesiclepedia VP_52551
Entrez Gene 52551
UniProt Q8BJU0  
 Sgta identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Sgta
Molecular Function
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    protein heterodimerization activity GO:0046982 ISO
    molecular adaptor activity GO:0060090 IBA
    BAT3 complex binding GO:1904288 IEA
    BAT3 complex binding GO:1904288 ISO
Biological Process
    post-translational protein targeting to endoplasmic reticulum membrane GO:0006620 IBA
    ERAD pathway GO:0036503 ISO
    ERAD pathway GO:0036503 ISS
    protein homooligomerization GO:0051260 ISO
    protein heterooligomerization GO:0051291 ISO
    chaperone-mediated protein folding GO:0061077 ISO
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISO
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISS
    negative regulation of ERAD pathway GO:1904293 ISO
    negative regulation of ERAD pathway GO:1904293 ISS
    positive regulation of ERAD pathway GO:1904294 IEA
    positive regulation of ERAD pathway GO:1904294 ISO
    negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 ISO
    negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 ISS
    positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 IEA
    positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    membrane GO:0016020 IBA
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
    TRC complex GO:0072380 IBA
    presynapse GO:0098793 ISO
    extrinsic component of synaptic vesicle membrane GO:0098850 ISO
 Experiment description of studies that identified Sgta in exosomes
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sgta
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Col1a2 12843
Co-fractionation Mus musculus
2 Ptn  
Co-fractionation Mus musculus
3 Ppib 19035
Co-fractionation Mus musculus
4 Sdc4 20971
Co-fractionation Mus musculus
5 Capza1 12340
Co-fractionation Mus musculus
6 Dnajc5 13002
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
7 Gdi1 14567
Co-fractionation Mus musculus
8 Hspa8 15481
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
9 Snap25 20614
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
10 Sgta 52551
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
11 Hspa4l  
Co-fractionation Mus musculus
12 Hsp90ab1 15516
Co-fractionation Mus musculus
13 Sod3  
Co-fractionation Mus musculus
14 Wsb2  
Co-fractionation Mus musculus
15 Hk1 15275
Co-fractionation Mus musculus
16 Asna1 56495
Co-fractionation Mus musculus
17 Strap 20901
Co-fractionation Mus musculus
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