Gene description for Gdi1
Gene name guanosine diphosphate (GDP) dissociation inhibitor 1
Gene symbol Gdi1
Other names/aliases GDIA
GDIalpha
Species Mus musculus
 Database cross references - Gdi1
ExoCarta ExoCarta_14567
Entrez Gene 14567
UniProt P50396  
 Gdi1 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Gdi1
Molecular Function
    Rab GDP-dissociation inhibitor activity GO:0005093 ISO
    GTPase activator activity GO:0005096 IEA
    Rab GTPase binding GO:0017137 ISO
Biological Process
    protein transport GO:0015031 IEA
    response to calcium ion GO:0051592 ISO
    regulation of catalytic activity GO:0050790 ISO
    negative regulation of protein targeting to membrane GO:0090315 ISO
    negative regulation of axonogenesis GO:0050771 ISO
Subcellular Localization
    protein complex GO:0043234 ISO
    neuron projection GO:0043005 ISO
    midbody GO:0030496 ISO
    cytoplasm GO:0005737 ISO
    myelin sheath GO:0043209 ISO
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified Gdi1 in exosomes
1
Experiment ID 33
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Gdi1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gdi1 is involved
PathwayEvidenceSource
Rho GTPase cycle IEA Reactome





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