Gene description for Dnajc5
Gene name DnaJ (Hsp40) homolog, subfamily C, member 5
Gene symbol Dnajc5
Other names/aliases 2610314I24Rik
AU018536
Csp
Species Mus musculus
 Database cross references - Dnajc5
ExoCarta ExoCarta_13002
Vesiclepedia VP_13002
Entrez Gene 13002
UniProt P60904  
 Dnajc5 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dnajc5
Molecular Function
    ATP-dependent protein binding GO:0043008 ISO
    glycoprotein binding GO:0001948 ISO
Biological Process
    negative regulation of neuron apoptotic process GO:0043524 IGI
Subcellular Localization
    membrane GO:0016020 ISO
    lysosomal membrane GO:0005765 ISO
    synaptic vesicle GO:0008021 IDA
    plasma membrane GO:0005886 ISO
    mitochondrion GO:0005739 ISO
    terminal bouton GO:0043195 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Dnajc5 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dnajc5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dnajc5 is involved
PathwayEvidenceSource
GABA synthesis, release, reuptake and degradation IEA Reactome





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