Gene description for Snap25
Gene name synaptosomal-associated protein 25
Gene symbol Snap25
Other names/aliases Bdr
GENA70
SNAP-25
SUP
sp
Species Mus musculus
 Database cross references - Snap25
ExoCarta ExoCarta_20614
Entrez Gene 20614
UniProt P60879  
 Snap25 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Snap25
Molecular Function
    SNAP receptor activity GO:0005484 IBA
    protein domain specific binding GO:0019904 ISO
    syntaxin-1 binding GO:0017075 ISO
    calcium-dependent protein binding GO:0048306 ISO
    myosin binding GO:0017022 ISO
    voltage-gated potassium channel activity GO:0005249 ISO
    SNARE binding GO:0000149 ISO
    ion channel binding GO:0044325 ISO
    protein binding GO:0005515 IPI
    protein N-terminus binding GO:0047485 ISO
Biological Process
    long-term synaptic potentiation GO:0060291 IMP
    locomotory behavior GO:0007626 IMP
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 ISO
    regulation of ion transmembrane transport GO:0034765 ISO
    regulation of neuron projection development GO:0010975 ISO
    synaptic vesicle fusion to presynaptic membrane GO:0031629 IBA
    regulation of establishment of protein localization GO:0070201 IMP
    sleep GO:0030431 ISO
    potassium ion transmembrane transport GO:0071805 ISO
    long-term memory GO:0007616 ISO
    positive regulation of hormone secretion GO:0046887 ISO
    exocytosis GO:0006887 IBA
    associative learning GO:0008306 IMP
    neurotransmitter secretion GO:0007269 IMP
    endosomal transport GO:0016197 ISO
    synaptic vesicle priming GO:0016082 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    SNARE complex GO:0031201 ISO
    filopodium GO:0030175 ISO
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 ISO
    voltage-gated potassium channel complex GO:0008076 ISO
    axonal growth cone GO:0044295 ISO
    cytoplasm GO:0005737 ISO
    synapse GO:0045202 IDA
    actin cytoskeleton GO:0015629 ISO
    membrane raft GO:0045121 ISO
    neuron projection GO:0043005 ISO
    cytosol GO:0005829 ISO
    intracellular organelle GO:0043229 ISO
    vesicle GO:0031982 ISO
    lamellipodium GO:0030027 ISO
    myelin sheath GO:0043209 IDA
    trans-Golgi network GO:0005802 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    growth cone GO:0030426 ISO
    terminal bouton GO:0043195 ISO
    synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044 ISO
    endosome GO:0005768 ISO
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex GO:0070033 ISO
    cell junction GO:0030054 IEA
    cell GO:0005623 IMP
    membrane GO:0016020 IDA
    axon GO:0030424 ISO
    BLOC-1 complex GO:0031083 ISO
    neuronal cell body GO:0043025 ISO
 Experiment description of studies that identified Snap25 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Snap25
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here