Gene description for Plp1
Gene name proteolipid protein (myelin) 1
Gene symbol Plp1
Other names/aliases DM20
Plp
jimpy
jp
msd
rsh
Species Mus musculus
 Database cross references - Plp1
ExoCarta ExoCarta_18823
Entrez Gene 18823
UniProt P60202  
 Plp1 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Plp1
Molecular Function
    structural molecule activity GO:0005198 ISO
    protein binding GO:0005515 IPI
    structural constituent of myelin sheath GO:0019911 ISO
Biological Process
    cell maturation GO:0048469 IMP
    astrocyte development GO:0014002 IGI
    axon development GO:0061564 IGI
    myelination GO:0042552 TAS
    central nervous system myelination GO:0022010 IMP
    long-chain fatty acid biosynthetic process GO:0042759 IMP
    glial cell differentiation GO:0010001 ISO
    axon ensheathment GO:0008366 IMP
    integrin-mediated signaling pathway GO:0007229 ISO
    inflammatory response GO:0006954 IGI
    positive regulation of gene expression GO:0010628 IMP
Subcellular Localization
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 ISO
    integral component of membrane GO:0016021 IEA
    myelin sheath GO:0043209 ISO
 Experiment description of studies that identified Plp1 in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Immunoelectron Microscopy
Western blotting
Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Plp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plp1 is involved
No pathways found





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