Gene description for Plp1
Gene name proteolipid protein (myelin) 1
Gene symbol Plp1
Other names/aliases DM20
Plp
jimpy
jp
msd
rsh
Species Mus musculus
 Database cross references - Plp1
ExoCarta ExoCarta_18823
Vesiclepedia VP_18823
Entrez Gene 18823
UniProt P60202  
 Plp1 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Plp1
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of myelin sheath GO:0019911 IBA
    structural constituent of myelin sheath GO:0019911 IEA
    structural constituent of myelin sheath GO:0019911 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
Biological Process
    inflammatory response GO:0006954 IGI
    axon ensheathment GO:0008366 IMP
    glial cell differentiation GO:0010001 ISO
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of gene expression GO:0010628 IMP
    astrocyte development GO:0014002 IGI
    central nervous system myelination GO:0022010 IBA
    central nervous system myelination GO:0022010 IMP
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    myelination GO:0042552 IGI
    myelination GO:0042552 IMP
    myelination GO:0042552 ISO
    myelination GO:0042552 TAS
    long-chain fatty acid biosynthetic process GO:0042759 IMP
    axon development GO:0061564 IBA
    axon development GO:0061564 IGI
    AMPA selective glutamate receptor signaling pathway GO:0098990 IEA
    AMPA selective glutamate receptor signaling pathway GO:0098990 ISO
    positive regulation of calcium ion transmembrane transport GO:1904427 IEA
    positive regulation of calcium ion transmembrane transport GO:1904427 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    integrin alphav-beta3 complex GO:0034683 IEA
    integrin alphav-beta3 complex GO:0034683 ISO
    myelin sheath GO:0043209 HDA
    myelin sheath GO:0043209 IBA
    myelin sheath GO:0043209 IDA
    myelin sheath GO:0043209 ISO
 Experiment description of studies that identified Plp1 in exosomes
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Immunoelectron Microscopy
Western blotting
Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Plp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Cox6b1  
Co-fractionation Mus musculus
3 Lancl1  
Co-fractionation Mus musculus
4 Syp  
Co-fractionation Mus musculus
5 MAPT  
Reconstituted Complex Homo sapiens
6 Dlg4  
Affinity Capture-MS Mus musculus
7 Prnp 19122
Affinity Capture-MS Mus musculus
8 Aph1b  
Affinity Capture-MS Mus musculus
9 Aldoc 11676
Co-fractionation Mus musculus
10 Aph1a 226548
Affinity Capture-MS Mus musculus
11 Diras2  
Co-fractionation Mus musculus
12 Snap25 20614
Co-fractionation Mus musculus
13 Htt  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Plp1 is involved
No pathways found





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