Gene description for Aldoc
Gene name aldolase C, fructose-bisphosphate
Gene symbol Aldoc
Other names/aliases AI847350
AU040929
Aldo3
Scrg2
Species Mus musculus
 Database cross references - Aldoc
ExoCarta ExoCarta_11676
Entrez Gene 11676
UniProt P05063  
 Aldoc identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Aldoc
Molecular Function
    cytoskeletal protein binding GO:0008092 ISO
    lyase activity GO:0016829 IEA
    catalytic activity GO:0003824 IEA
    fructose-bisphosphate aldolase activity GO:0004332 NAS
Biological Process
    fructose 1,6-bisphosphate metabolic process GO:0030388 ISO
    glycolytic process GO:0006096 IEA
    aging GO:0007568 ISO
    protein homotetramerization GO:0051289 ISO
    protein heterotetramerization GO:0051290 ISO
    apoptotic process GO:0006915 ISO
Subcellular Localization
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    axon GO:0030424 ISO
 Experiment description of studies that identified Aldoc in exosomes
1
Experiment ID 264
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aldoc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldoc is involved
PathwayEvidenceSource
Gluconeogenesis IEA Reactome
Glycolysis IEA Reactome





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