Gene description for Aph1a
Gene name anterior pharynx defective 1a homolog (C. elegans)
Gene symbol Aph1a
Other names/aliases 6530402N02Rik
APH-1a
Species Mus musculus
 Database cross references - Aph1a
ExoCarta ExoCarta_226548
Entrez Gene 226548
UniProt Q8BVF7  
 Aph1a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Aph1a
Molecular Function
    endopeptidase activity GO:0004175 IMP
    peptidase activity GO:0008233 ISA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of catalytic activity GO:0043085 ISO
    protein processing GO:0016485 ISO
    Notch receptor processing GO:0007220 ISO
    membrane protein ectodomain proteolysis GO:0006509 ISO
    membrane protein intracellular domain proteolysis GO:0031293 ISO
    amyloid precursor protein catabolic process GO:0042987 ISO
    metanephros development GO:0001656 IMP
    Notch signaling pathway GO:0007219 IEA
    proteolysis GO:0006508 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    integral component of plasma membrane GO:0005887 ISO
    Golgi apparatus GO:0005794 ISO
    integral component of membrane GO:0016021 ISA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Aph1a in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Aph1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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