Gene description for Mbp
Gene name myelin basic protein
Gene symbol Mbp
Other names/aliases C76307
Hmbpr
R75289
golli-mbp
mld
shi
Species Mus musculus
 Database cross references - Mbp
ExoCarta ExoCarta_17196
Entrez Gene 17196
UniProt P04370  
 Mbp identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Mbp
Molecular Function
    structural constituent of myelin sheath GO:0019911 IEA
    protease binding GO:0002020 IPI
Biological Process
    membrane organization GO:0061024 IDA
    myelination GO:0042552 IDA
    response to toxic substance GO:0009636 IDA
Subcellular Localization
    neuronal cell body GO:0043025 IDA
    cell projection GO:0042995 IDA
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 IEA
    myelin sheath GO:0043209 IDA
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
    cell periphery GO:0071944 IDA
    internode region of axon GO:0033269 IDA
 Experiment description of studies that identified Mbp in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Mbp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mbp is involved
No pathways found





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