Gene description for Prnp
Gene name prion protein
Gene symbol Prnp
Other names/aliases AA960666
Species Mus musculus
 Database cross references - Prnp
ExoCarta ExoCarta_19122
Entrez Gene 19122
UniProt P04925  
 Prnp identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Prnp
Molecular Function
    identical protein binding GO:0042802 ISO
    copper ion binding GO:0005507 ISO
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    ion channel binding GO:0044325 ISO
    ATP-dependent protein binding GO:0043008 ISO
    tubulin binding GO:0015631 ISO
    microtubule binding GO:0008017 ISO
    chaperone binding GO:0051087 ISO
Biological Process
    response to copper ion GO:0046688 ISO
    nucleobase-containing compound metabolic process GO:0006139 TAS
    response to oxidative stress GO:0006979 IDA
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IMP
    cellular response to copper ion GO:0071280 ISO
    negative regulation of T cell receptor signaling pathway GO:0050860 IMP
    learning or memory GO:0007611 ISO
    negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    regulation of potassium ion transmembrane transport GO:1901379 IGI
    protein homooligomerization GO:0051260 IEA
    cellular response to drug GO:0035690 IDA
    negative regulation of interleukin-17 production GO:0032700 IMP
    negative regulation of activated T cell proliferation GO:0046007 IMP
    response to cadmium ion GO:0046686 ISO
    negative regulation of interferon-gamma production GO:0032689 IMP
    regulation of protein localization GO:0032880 IMP
    negative regulation of interleukin-2 production GO:0032703 IMP
    negative regulation of protein phosphorylation GO:0001933 IMP
    cellular copper ion homeostasis GO:0006878 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    endoplasmic reticulum GO:0005783 IDA
    extracellular exosome GO:0070062 ISO
    membrane raft GO:0045121 TAS
    membrane GO:0016020 ISO
    anchored component of membrane GO:0031225 IEA
    cell surface GO:0009986 ISO
    mitochondrial outer membrane GO:0005741 ISO
    cytoplasm GO:0005737 ISO
    cell GO:0005623 TAS
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Prnp in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
Immunoelectron Microscopy
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Prnp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prnp is involved
NCAM1 interactions IEA Reactome

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