Gene description for L1cam
Gene name L1 cell adhesion molecule
Gene symbol L1cam
Other names/aliases CD171
Species Mus musculus
 Database cross references - L1cam
ExoCarta ExoCarta_16728
Entrez Gene 16728
 L1cam identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for L1cam
Molecular Function
    identical protein binding GO:0042802 IDA
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 ISO
    protein self-association GO:0043621 IPI
    sialic acid binding GO:0033691 IDA
    integrin binding GO:0005178 IDA
Biological Process
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    axon guidance GO:0007411 IMP
    homotypic cell-cell adhesion GO:0034109 IMP
    positive regulation of cell-cell adhesion GO:0022409 IMP
    neuron projection development GO:0031175 IMP
    leukocyte cell-cell adhesion GO:0007159 IMP
    multicellular organismal development GO:0007275 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IMP
    cell differentiation GO:0030154 IEA
    cell surface receptor signaling pathway GO:0007166 IDA
    nervous system development GO:0007399 IEA
    cell-cell adhesion mediated by integrin GO:0033631 IMP
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IMP
    cell adhesion GO:0007155 IEA
Subcellular Localization
    membrane raft GO:0045121 ISO
    cell surface GO:0009986 ISO
    dendrite GO:0030425 ISO
    terminal bouton GO:0043195 IDA
    presynaptic membrane GO:0042734 IDA
    focal adhesion GO:0005925 ISO
    external side of plasma membrane GO:0009897 IDA
    axon GO:0030424 ISO
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IDA
    neuronal cell body GO:0043025 ISO
    integral component of membrane GO:0016021 IEA
    endosome GO:0005768 ISO
 Experiment description of studies that identified L1cam in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for L1cam
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which L1cam is involved
No pathways found

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