Gene description for L1cam
Gene name L1 cell adhesion molecule
Gene symbol L1cam
Other names/aliases CD171
L1
N-CAM-L1
NCAM-L1
Species Mus musculus
 Database cross references - L1cam
ExoCarta ExoCarta_16728
Vesiclepedia VP_16728
Entrez Gene 16728
 L1cam identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for L1cam
Molecular Function
    integrin binding GO:0005178 IDA
    protein binding GO:0005515 IPI
    axon guidance receptor activity GO:0008046 IBA
    protein domain specific binding GO:0019904 IEA
    protein domain specific binding GO:0019904 ISO
    PDZ domain binding GO:0030165 ISO
    sialic acid binding GO:0033691 IDA
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    regulation of protein phosphorylation GO:0001932 ISO
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IMP
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IMP
    leukocyte cell-cell adhesion GO:0007159 IMP
    cell-matrix adhesion GO:0007160 IEA
    cell-matrix adhesion GO:0007160 ISO
    cell-matrix adhesion GO:0007160 ISS
    cell surface receptor signaling pathway GO:0007166 IDA
    axon guidance GO:0007411 IDA
    axon guidance GO:0007411 IEA
    axon guidance GO:0007411 IGI
    axon guidance GO:0007411 IMP
    axon guidance GO:0007411 ISO
    axonal fasciculation GO:0007413 ISO
    positive regulation of cell-substrate adhesion GO:0010811 ISO
    regulation of neuron projection development GO:0010975 ISO
    cell migration GO:0016477 IEA
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    calcium-mediated signaling GO:0019722 IDA
    positive regulation of cell-cell adhesion GO:0022409 IMP
    neuron projection development GO:0031175 IDA
    neuron projection development GO:0031175 IMP
    neuron projection development GO:0031175 ISO
    cell-cell adhesion mediated by integrin GO:0033631 IMP
    homotypic cell-cell adhesion GO:0034109 IMP
    protein localization to plasma membrane raft GO:0044860 ISO
    positive regulation of axon extension GO:0045773 ISO
    positive regulation of axon extension GO:0045773 ISS
    modulation of chemical synaptic transmission GO:0050804 ISO
    synapse organization GO:0050808 IBA
    synapse organization GO:0050808 IEA
    synapse organization GO:0050808 ISO
    synapse organization GO:0050808 ISS
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    regulation of synapse assembly GO:0051963 IDA
    regulation of synapse assembly GO:0051963 IMP
    axon development GO:0061564 ISO
    regulation of ERK1 and ERK2 cascade GO:0070372 ISO
    cerebellar neuron development GO:0098749 ISO
    maintenance of synapse structure GO:0099558 IDA
    maintenance of synapse structure GO:0099558 IMP
    response to toluene GO:1901424 ISO
Subcellular Localization
    endosome GO:0005768 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    axon GO:0030424 IBA
    axon GO:0030424 IEA
    axon GO:0030424 ISO
    dendrite GO:0030425 ISO
    presynaptic membrane GO:0042734 IDA
    presynaptic membrane GO:0042734 IDA
    neuronal cell body GO:0043025 IBA
    neuronal cell body GO:0043025 IEA
    neuronal cell body GO:0043025 ISO
    neuronal cell body GO:0043025 ISS
    terminal bouton GO:0043195 IDA
    dendritic growth cone GO:0044294 ISO
    axonal growth cone GO:0044295 ISO
    axonal growth cone GO:0044295 ISS
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 ISO
    glutamatergic synapse GO:0098978 IDA
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IMP
 Experiment description of studies that identified L1cam in exosomes
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for L1cam
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Erbb3  
Co-localization Mus musculus
2 RANBP9 10048
Reconstituted Complex Homo sapiens
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Prnp 19122
Affinity Capture-MS Mus musculus
5 Ranbp9  
Co-purification Mus musculus
6 Gapdh 14433
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which L1cam is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here