Gene description for Dnm1
Gene name dynamin 1
Gene symbol Dnm1
Other names/aliases AI838169
Dnm
Ftfl
mKIAA4093
Species Mus musculus
 Database cross references - Dnm1
ExoCarta ExoCarta_13429
Vesiclepedia VP_13429
Entrez Gene 13429
UniProt P39053  
 Dnm1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dnm1
Molecular Function
    identical protein binding GO:0042802 ISO
    GTP binding GO:0005525 IEA
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 ISO
    protein C-terminus binding GO:0008022 ISO
    GTPase activity GO:0003924 IEA
    hydrolase activity GO:0016787 IEA
    nitric-oxide synthase binding GO:0050998 ISO
    protein kinase binding GO:0019901 IPI
    D2 dopamine receptor binding GO:0031749 ISO
    protein dimerization activity GO:0046983 IDA
    protein binding GO:0005515 IPI
    protein complex binding GO:0032403 ISO
Biological Process
    endocytosis GO:0006897 ISO
    endosome organization GO:0007032 ISO
    toxin transport GO:1901998 IMP
    G-protein coupled receptor internalization GO:0002031 ISO
    receptor-mediated endocytosis GO:0006898 ISO
    synaptic transmission, GABAergic GO:0051932 IMP
    sensory perception of sound GO:0007605 IMP
    receptor internalization GO:0031623 ISO
    protein tetramerization GO:0051262 IMP
    adult locomotory behavior GO:0008344 IMP
    positive regulation of synaptic vesicle recycling GO:1903423 ISO
    clathrin-mediated endocytosis GO:0072583 IEA
Subcellular Localization
    myelin sheath GO:0043209 IDA
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    varicosity GO:0043196 ISO
    synapse GO:0045202 ISO
    cytoskeleton GO:0005856 IEA
    Golgi apparatus GO:0005794 ISO
    protein complex GO:0043234 ISO
    photoreceptor inner segment GO:0001917 IDA
    extracellular exosome GO:0070062 ISO
    microtubule GO:0005874 IEA
    membrane coat GO:0030117 IDA
    synaptic vesicle GO:0008021 ISO
 Experiment description of studies that identified Dnm1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dnm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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