Gene description for Cyfip1
Gene name cytoplasmic FMR1 interacting protein 1
Gene symbol Cyfip1
Other names/aliases E030028J09Rik
P140SRA-1
P140sra1
Shyc
Sra-1
Sra1
l(7)1Rl
l71Rl
l7Rl1
mKIAA0068
pl-1
Species Mus musculus
 Database cross references - Cyfip1
ExoCarta ExoCarta_20430
Entrez Gene 20430
UniProt Q7TMB8  
 Cyfip1 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Cyfip1
Molecular Function
    profilin binding GO:0005522 TAS
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    Rac GTPase binding GO:0048365 ISO
    protein complex binding GO:0032403 ISO
Biological Process
    axon extension GO:0048675 ISO
    lamellipodium assembly GO:0030032 IDA
    cell differentiation GO:0030154 IEA
    multicellular organismal development GO:0007275 IEA
    Rac protein signal transduction GO:0016601 ISO
    positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 ISO
    cognition GO:0050890 ISO
    nervous system development GO:0007399 IEA
    regulation of cell shape GO:0008360 IEA
Subcellular Localization
    neuron projection GO:0043005 IDA
    cytoplasm GO:0005737 IEA
    cell projection GO:0042995 IEA
    lamellipodium GO:0030027 IDA
    focal adhesion GO:0005925 ISO
    synapse GO:0045202 IEA
    extracellular exosome GO:0070062 ISO
    cell junction GO:0030054 IEA
    mRNA cap binding complex GO:0005845 IDA
    SCAR complex GO:0031209 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified Cyfip1 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cyfip1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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