Gene description for P2rx7
Gene name	purinergic receptor P2X, ligand-gated ion channel, 7
Gene symbol	P2rx7
Other names/aliases	AI467586 P2X(7) P2X7R
Species	Mus musculus
Database cross references - P2rx7
ExoCarta	ExoCarta_18439
Entrez Gene	18439
UniProt	Q9Z1M0
P2rx7 identified in exosomes derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for P2rx7

Molecular Function     receptor activity GO:0004872 IMP     protein binding GO:0005515 IPI     lipopolysaccharide binding GO:0001530 IDA     ion channel activity GO:0005216 IEA     extracellular ATP-gated cation channel activity GO:0004931 ISO     channel activity GO:0015267 ISO     ATP binding GO:0005524 IMP     purinergic nucleotide receptor activity GO:0001614 ISO Biological Process     inflammatory response GO:0006954 IMP     positive regulation of cytokine secretion GO:0050715 IMP     membrane budding GO:0006900 IMP     mitochondrion organization GO:0007005 IDA     response to organic cyclic compound GO:0014070 IDA     membrane protein ectodomain proteolysis GO:0006509 IMP     phospholipid translocation GO:0045332 IDA     phagolysosome assembly GO:0001845 IMP     cellular response to dsRNA GO:0071359 IMP     NAD transport GO:0043132 IMP     positive regulation of prostaglandin secretion GO:0032308 IMP     protein oligomerization GO:0051259 IDA     activation of MAPK activity GO:0000187 IMP     membrane depolarization GO:0051899 ISO     cation transmembrane transport GO:0098655 IMP     extrinsic apoptotic signaling pathway GO:0097191 IMP     response to bacterium GO:0009617 IMP     T cell homeostasis GO:0043029 IMP     positive regulation of ossification GO:0045778 IMP     synaptic vesicle exocytosis GO:0016079 IMP     purinergic nucleotide receptor signaling pathway GO:0035590 ISO     skeletal system morphogenesis GO:0048705 IMP     positive regulation of mitochondrial depolarization GO:0051901 IMP     negative regulation of bone resorption GO:0045779 IMP     positive regulation of gene expression GO:0010628 ISO     bleb assembly GO:0032060 ISO     response to lipopolysaccharide GO:0032496 IMP     positive regulation of glycolytic process GO:0045821 ISO     response to fluid shear stress GO:0034405 IMP     multicellular organismal protein catabolic process GO:0044254 IDA     response to drug GO:0042493 IMP     protein phosphorylation GO:0006468 IMP     response to calcium ion GO:0051592 IMP     pore complex assembly GO:0046931 ISO     positive regulation of protein secretion GO:0050714 IDA     protein processing GO:0016485 IMP     T cell proliferation GO:0042098 IMP     plasma membrane organization GO:0007009 IDA     collagen metabolic process GO:0032963 IMP     phospholipid scrambling GO:0017121 ISO     positive regulation of bone mineralization GO:0030501 IMP     positive regulation of glutamate secretion GO:0014049 IMP     response to organic substance GO:0010033 IMP     programmed cell death GO:0012501 IMP     sensory perception of pain GO:0019233 IMP     defense response to Gram-positive bacterium GO:0050830 IMP     cellular response to organic cyclic compound GO:0071407 IDA     positive regulation of MAPK cascade GO:0043410 IMP     positive regulation of apoptotic process GO:0043065 IMP     release of sequestered calcium ion into cytosol GO:0051209 IMP     transport GO:0006810 IEA     positive regulation of interleukin-6 production GO:0032755 IMP     response to zinc ion GO:0010043 IMP     positive regulation of catalytic activity GO:0043085 IMP     cytolysis GO:0019835 IMP     positive regulation of calcium ion transport into cytosol GO:0010524 ISO     response to ATP GO:0033198 ISO     calcium ion transport GO:0006816 IMP     positive regulation of interleukin-1 beta secretion GO:0050718 ISO     homeostasis of number of cells within a tissue GO:0048873 IMP     gene expression GO:0010467 IMP     cation transport GO:0006812 IMP     positive regulation of interleukin-1 alpha secretion GO:0050717 IMP     positive regulation of lymphocyte apoptotic process GO:0070230 IMP     positive regulation of gamma-aminobutyric acid secretion GO:0014054 IMP     ion transport GO:0006811 IEA     positive regulation of T cell mediated cytotoxicity GO:0001916 IMP     cell morphogenesis GO:0000902 IMP     phospholipid transfer to membrane GO:0006649 IMP     negative regulation of cell volume GO:0045794 ISO     positive regulation of ion transmembrane transport GO:0034767 ISO     reactive oxygen species metabolic process GO:0072593 IMP     response to electrical stimulus GO:0051602 IMP     positive regulation of bleb assembly GO:1904172 ISO     positive regulation of protein phosphorylation GO:0001934 IMP     negative regulation of MAPK cascade GO:0043409 IDA     response to mechanical stimulus GO:0009612 IMP     cell volume homeostasis GO:0006884 IDA     cellular response to extracellular stimulus GO:0031668 IMP     positive regulation of interleukin-1 beta production GO:0032731 IMP     ceramide biosynthetic process GO:0046513 IDA Subcellular Localization     neuromuscular junction GO:0031594 IDA     synapse GO:0045202 IDA     integral component of nuclear inner membrane GO:0005639 IBA     integral component of membrane GO:0016021 IEA     integral component of plasma membrane GO:0005887 ISS     cell-cell junction GO:0005911 IDA     cytosol GO:0005829 IMP     plasma membrane GO:0005886 ISO     external side of plasma membrane GO:0009897 IDA     neuronal cell body GO:0043025 IDA     membrane GO:0016020 ISO     intracellular GO:0005622 IMP