Gene description for Ipo4
Gene name importin 4
Gene symbol Ipo4
Other names/aliases 8430408O15Rik
AA409693
Imp4a
RanBP4
Species Mus musculus
 Database cross references - Ipo4
ExoCarta ExoCarta_75751
Entrez Gene 75751
UniProt Q8VI75  
 Ipo4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ipo4
Molecular Function
    protein binding GO:0005515 IPI
    Ran GTPase binding GO:0008536 IEA
Biological Process
    ribosome biogenesis GO:0042254 ISA
    transport GO:0006810 IEA
    ribosomal protein import into nucleus GO:0006610 ISA
    DNA replication-independent nucleosome assembly GO:0006336 ISO
    DNA replication-dependent nucleosome assembly GO:0006335 ISO
    protein transport GO:0015031 IEA
    intracellular protein transport GO:0006886 IEA
Subcellular Localization
    protein complex GO:0043234 ISO
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
    membrane GO:0016020 ISO
    cell GO:0005623 ISA
    intracellular GO:0005622 ISA
    nuclear chromatin GO:0000790 ISO
 Experiment description of studies that identified Ipo4 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ipo4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ipo4 is involved
No pathways found





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