Gene description for Shank1
Gene name SH3/ankyrin domain gene 1
Gene symbol Shank1
Other names/aliases -
Species Mus musculus
 Database cross references - Shank1
ExoCarta ExoCarta_243961
Entrez Gene 243961
UniProt D3YZU1  
 Shank1 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Shank1
Molecular Function
    ankyrin repeat binding GO:0071532 ISO
    somatostatin receptor binding GO:0031877 ISO
    scaffold protein binding GO:0097110 ISO
    ionotropic glutamate receptor binding GO:0035255 ISO
    protein C-terminus binding GO:0008022 ISO
    receptor signaling complex scaffold activity GO:0030159 ISO
    GKAP/Homer scaffold activity GO:0030160 ISO
    identical protein binding GO:0042802 ISO
    protein complex binding GO:0032403 ISO
    SH3 domain binding GO:0017124 ISO
Biological Process
    determination of affect GO:0050894 ISO
    righting reflex GO:0060013 IMP
    nervous system development GO:0007399 IEA
    associative learning GO:0008306 IMP
    neuromuscular process controlling balance GO:0050885 IMP
    adult behavior GO:0030534 ISO
    regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:2000311 IMP
    olfactory behavior GO:0042048 IMP
    cell differentiation GO:0030154 IEA
    synapse maturation GO:0060074 ISO
    vocalization behavior GO:0071625 ISO
    habituation GO:0046959 IMP
    social behavior GO:0035176 ISO
    long-term memory GO:0007616 IMP
    protein localization to synapse GO:0035418 IMP
    dendritic spine morphogenesis GO:0060997 IMP
    positive regulation of dendritic spine development GO:0060999 ISO
    protein complex assembly GO:0006461 ISO
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 IMP
    negative regulation of actin filament bundle assembly GO:0032232 IDA
Subcellular Localization
    ionotropic glutamate receptor complex GO:0008328 IDA
    dendritic spine GO:0043197 ISO
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 IEA
    postsynaptic membrane GO:0045211 ISO
    synapse GO:0045202 ISO
    cell junction GO:0030054 IEA
    dendrite GO:0030425 IDA
    plasma membrane GO:0005886 IDA
    N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 ISO
    neuron projection GO:0043005 IDA
    neuronal postsynaptic density GO:0097481 IDA
    excitatory synapse GO:0060076 IDA
 Experiment description of studies that identified Shank1 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Shank1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Shank1 is involved
No pathways found





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