Gene description for Dync1h1
Gene name dynein cytoplasmic 1 heavy chain 1
Gene symbol Dync1h1
Other names/aliases 9930018I23Rik
AI894280
DHC1
DHC1a
DNCL
Dnchc1
Dnec1
Dnecl
Loa
MAP1C
P22
Swl
mKIAA0325
Species Mus musculus
 Database cross references - Dync1h1
ExoCarta ExoCarta_13424
Entrez Gene 13424
UniProt Q9JHU4  
 Dync1h1 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Dync1h1
Molecular Function
    motor activity GO:0003774 IEA
    microtubule motor activity GO:0003777 IEA
    protein binding GO:0005515 IPI
    dynein light intermediate chain binding GO:0051959 IPI
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    poly(A) RNA binding GO:0044822 ISO
    ATPase activity GO:0016887 IEA
Biological Process
    stress granule assembly GO:0034063 IMP
    cytoplasmic mRNA processing body assembly GO:0033962 IMP
    cilium movement GO:0003341 IC
    establishment of spindle localization GO:0051293 ISO
    microtubule-based movement GO:0007018 IEA
    transport GO:0006810 IEA
Subcellular Localization
    filopodium GO:0030175 IDA
    cytoskeleton GO:0005856 IEA
    cytoplasmic dynein complex GO:0005868 ISM
    centrosome GO:0005813 ISO
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 ISO
    dynein complex GO:0030286 IEA
    extracellular exosome GO:0070062 ISO
    microtubule GO:0005874 ISO
 Experiment description of studies that identified Dync1h1 in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dync1h1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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