Gene description for DYNC1I2
Gene name dynein, cytoplasmic 1, intermediate chain 2
Gene symbol DYNC1I2
Other names/aliases DNCI2
IC2
Species Homo sapiens
 Database cross references - DYNC1I2
ExoCarta ExoCarta_1781
Entrez Gene 1781
HGNC 2964
MIM 603331
UniProt Q13409  
 DYNC1I2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for DYNC1I2
Molecular Function
    protein binding GO:0005515 IPI
    microtubule motor activity GO:0003777 NAS
Biological Process
    metabolic process GO:0008152 NAS
    viral process GO:0016032 IEA
    microtubule-based movement GO:0007018 NAS
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    organelle organization GO:0006996 TAS
    mitotic cell cycle GO:0000278 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    transport GO:0006810 IEA
Subcellular Localization
    cytoplasmic dynein complex GO:0005868 IEA
    centrosome GO:0005813 IDA
    cytoplasm GO:0005737 NAS
    vesicle GO:0031982 IDA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 IDA
 Experiment description of studies that identified DYNC1I2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DYNC1I2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCTN1 1639
Affinity Capture-MS Homo sapiens
2 DYNLL1 8655
Affinity Capture-MS Homo sapiens
3 TCTE1L  
Two-hybrid Homo sapiens
View the network image/svg+xml



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