Gene description for MAPK3
Gene name mitogen-activated protein kinase 3
Gene symbol MAPK3
Other names/aliases ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
Species Homo sapiens
 Database cross references - MAPK3
ExoCarta ExoCarta_5595
Vesiclepedia VP_5595
Entrez Gene 5595
HGNC 6877
MIM 601795
UniProt P27361  
 MAPK3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for MAPK3
Molecular Function
    phosphotyrosine residue binding GO:0001784 IEA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    JUN kinase activity GO:0004705 IEA
    MAP kinase activity GO:0004707 IDA
    MAP kinase activity GO:0004707 NAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    phosphatase binding GO:0019902 IPI
    identical protein binding GO:0042802 IPI
    protein serine kinase activity GO:0106310 IEA
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    MAPK cascade GO:0000165 NAS
    DNA-templated transcription GO:0006351 IEA
    protein phosphorylation GO:0006468 IDA
    apoptotic process GO:0006915 IEA
    cell surface receptor signaling pathway GO:0007166 IBA
    JNK cascade GO:0007254 IEA
    insulin receptor signaling pathway GO:0008286 IEA
    positive regulation of macrophage chemotaxis GO:0010759 IGI
    Schwann cell development GO:0014044 IEA
    phosphorylation GO:0016310 IDA
    sensory perception of pain GO:0019233 IEA
    regulation of ossification GO:0030278 IEA
    BMP signaling pathway GO:0030509 IMP
    regulation of cellular pH GO:0030641 IEA
    thyroid gland development GO:0030878 IEA
    positive regulation of cyclase activity GO:0031281 IMP
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    positive regulation of telomere maintenance GO:0032206 IMP
    regulation of stress-activated MAPK cascade GO:0032872 TAS
    cellular response to amino acid starvation GO:0034198 IDA
    intracellular signal transduction GO:0035556 IBA
    peptidyl-tyrosine autophosphorylation GO:0038083 IDA
    ERBB2-ERBB3 signaling pathway GO:0038133 IEA
    outer ear morphogenesis GO:0042473 IEA
    myelination GO:0042552 IEA
    signal transduction in response to DNA damage GO:0042770 IDA
    response to exogenous dsRNA GO:0043330 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    thymus development GO:0048538 IEA
    modulation of chemical synaptic transmission GO:0050804 IEA
    cartilage development GO:0051216 IEA
    stress-activated MAPK cascade GO:0051403 IDA
    regulation of cytoskeleton organization GO:0051493 TAS
    Bergmann glial cell differentiation GO:0060020 IEA
    face development GO:0060324 IEA
    lung morphogenesis GO:0060425 IEA
    trachea formation GO:0060440 IEA
    cardiac neural crest cell development involved in heart development GO:0061308 IEA
    ERK1 and ERK2 cascade GO:0070371 TAS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    interleukin-1-mediated signaling pathway GO:0070498 IMP
    response to epidermal growth factor GO:0070849 IDA
    cellular response to mechanical stimulus GO:0071260 IEP
    cellular response to tumor necrosis factor GO:0071356 IEA
    caveolin-mediated endocytosis GO:0072584 TAS
    regulation of Golgi inheritance GO:0090170 TAS
    xenophagy GO:0098792 IEA
    positive regulation of macrophage proliferation GO:0120041 IGI
    negative regulation of TORC1 signaling GO:1904262 IDA
    positive regulation of xenophagy GO:1904417 IEA
    regulation of early endosome to late endosome transport GO:2000641 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 TAS
    nuclear envelope GO:0005635 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 TAS
    early endosome GO:0005769 TAS
    late endosome GO:0005770 TAS
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi apparatus GO:0005794 TAS
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 TAS
    plasma membrane GO:0005886 ISS
    caveola GO:0005901 ISS
    caveola GO:0005901 TAS
    focal adhesion GO:0005925 TAS
    pseudopodium GO:0031143 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified MAPK3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 189
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 190
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
17
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
18
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
22
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MAPK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYMPK 8189
Affinity Capture-MS Homo sapiens
2 CELF1 10658
Affinity Capture-MS Homo sapiens
3 AKR1C1 1645
Two-hybrid Homo sapiens
4 HDAC4  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
5 ARHGEF2 9181
Co-fractionation Homo sapiens
6 UBE4B 10277
Biochemical Activity Homo sapiens
7 UBL4A 8266
Affinity Capture-MS Homo sapiens
8 CUEDC2  
Biochemical Activity Homo sapiens
9 PCF11 51585
Affinity Capture-MS Homo sapiens
10 TTYH3 80727
Two-hybrid Homo sapiens
11 TH  
Biochemical Activity Homo sapiens
12 RIN3  
Affinity Capture-MS Homo sapiens
13 DUSP8  
Affinity Capture-MS Homo sapiens
14 DAPK1 1612
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
15 SP1  
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
16 PDCD1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
17 EPB41L5 57669
Affinity Capture-MS Homo sapiens
18 UBA1 7317
Co-fractionation Homo sapiens
19 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 NUPL1 9818
Two-hybrid Homo sapiens
21 IP6K3  
Affinity Capture-MS Homo sapiens
22 RPS6KA4 8986
Affinity Capture-Western Homo sapiens
23 SYNE2 23224
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 CREM  
Biochemical Activity Homo sapiens
25 MTMR12 54545
Co-fractionation Homo sapiens
26 RET 5979
Co-localization Homo sapiens
27 LTN1 26046
Affinity Capture-MS Homo sapiens
28 PNKD  
Affinity Capture-MS Homo sapiens
29 RFFL 117584
Affinity Capture-MS Homo sapiens
30 CLIC5 53405
Affinity Capture-MS Homo sapiens
31 HMMR  
Co-fractionation Homo sapiens
32 APEX1 328
Affinity Capture-RNA Homo sapiens
33 CAPZB 832
Affinity Capture-MS Homo sapiens
34 RPS6KA3 6197
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
35 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ERF  
Affinity Capture-MS Homo sapiens
37 PRDX3 10935
Affinity Capture-MS Homo sapiens
38 USO1 8615
Affinity Capture-Western Homo sapiens
39 GSE1 23199
Affinity Capture-MS Homo sapiens
40 MCM2 4171
Affinity Capture-MS Homo sapiens
41 NUP153 9972
Reconstituted Complex Homo sapiens
42 WDR83  
Affinity Capture-Western Homo sapiens
43 SCRIB 23513
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
44 SPANXN4  
Affinity Capture-MS Homo sapiens
45 ZDHHC11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 IQGAP1 8826
Co-purification Homo sapiens
47 SRC 6714
Affinity Capture-Western Homo sapiens
48 MAPK14 1432
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Co-localization Homo sapiens
49 DUSP5  
Biochemical Activity Homo sapiens
50 ATF2  
Co-localization Homo sapiens
51 PTPRR  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
52 SURF6  
Affinity Capture-MS Homo sapiens
53 PEA15 8682
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 LAMTOR3 8649
Affinity Capture-Western Homo sapiens
55 MBP 4155
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
56 TRIM54  
Two-hybrid Homo sapiens
57 TULP3 7289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 VDAC1 7416
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
59 ZNF219  
Two-hybrid Homo sapiens
60 ATG16L1 55054
Co-fractionation Homo sapiens
61 TIAL1 7073
Affinity Capture-MS Homo sapiens
62 CDC23 8697
Two-hybrid Homo sapiens
63 RPS6KA2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
64 VDR  
Biochemical Activity Homo sapiens
65 FOXP2 93986
Two-hybrid Homo sapiens
66 BTBD10 84280
Two-hybrid Homo sapiens
67 NTMT1 28989
Co-fractionation Homo sapiens
68 KIF14 9928
Affinity Capture-MS Homo sapiens
69 GALE 2582
Co-fractionation Homo sapiens
70 PRNP 5621
Affinity Capture-MS Homo sapiens
71 CSTF2T  
Affinity Capture-MS Homo sapiens
72 GTF2I 2969
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
73 MAPK1 5594
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
74 PFN1 5216
Affinity Capture-MS Homo sapiens
75 PLA2G4A 5321
Affinity Capture-Western Homo sapiens
76 GEMIN5 25929
Affinity Capture-MS Homo sapiens
77 ITGB3 3690
Biochemical Activity Homo sapiens
78 STAR  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
79 ATF7IP 55729
Affinity Capture-MS Homo sapiens
80 MAPK3 5595
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
81 ZNF444  
Affinity Capture-MS Homo sapiens
82 BCL2L11  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
83 USP21  
Biochemical Activity Homo sapiens
84 PAK2 5062
Co-fractionation Homo sapiens
85 COMMD8 54951
Co-fractionation Homo sapiens
86 PTPN5  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 PTGS2 5743
Affinity Capture-Western Homo sapiens
88 METTL2B 55798
Co-fractionation Homo sapiens
89 LYN 4067
Affinity Capture-Western Homo sapiens
90 SCAND1  
Two-hybrid Homo sapiens
91 TEK  
Affinity Capture-MS Homo sapiens
92 HTT 3064
Affinity Capture-MS Homo sapiens
93 TPD52 7163
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
94 STAB2 55576
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
95 TPM2 7169
Affinity Capture-MS Homo sapiens
96 UBR5 51366
Affinity Capture-Western Homo sapiens
97 PTPRE 5791
Affinity Capture-Western Homo sapiens
98 JUN 3725
Biochemical Activity Homo sapiens
99 ELK4 2005
Biochemical Activity Homo sapiens
100 VCP 7415
Affinity Capture-MS Homo sapiens
101 SEPT8 23176
Co-fractionation Homo sapiens
102 MAGED1 9500
Two-hybrid Homo sapiens
103 PTGDR  
Affinity Capture-Western Homo sapiens
104 CRP  
Two-hybrid Homo sapiens
105 PPP1R21 129285
Affinity Capture-MS Homo sapiens
106 ETNK2  
Affinity Capture-MS Homo sapiens
107 WDR43 23160
Affinity Capture-MS Homo sapiens
108 TTC9C 283237
Affinity Capture-MS Homo sapiens
109 UBTF 7343
Biochemical Activity Homo sapiens
110 PML 5371
Affinity Capture-Western Homo sapiens
111 SNRNP27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 BRAF  
Phenotypic Enhancement Homo sapiens
Co-localization Homo sapiens
113 SREBF2 6721
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
114 SREBF1 6720
Biochemical Activity Homo sapiens
115 ETV1  
Biochemical Activity Homo sapiens
116 DNM1L 10059
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
117 ATP5B 506
Affinity Capture-MS Homo sapiens
118 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
119 RPS6KA1 6195
Affinity Capture-Western Homo sapiens
120 CHEK2  
Co-fractionation Homo sapiens
121 RPS6KA6 27330
Two-hybrid Homo sapiens
122 NAB2 4665
Two-hybrid Homo sapiens
123 DYNC1I2 1781
Affinity Capture-MS Homo sapiens
124 PTPN11 5781
Co-localization Homo sapiens
125 DUSP1  
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
126 SPIB  
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
127 RXRA 6256
Biochemical Activity Homo sapiens
128 CSTF1 1477
Co-fractionation Homo sapiens
129 HTRA2 27429
Biochemical Activity Homo sapiens
130 PXN 5829
Co-fractionation Homo sapiens
131 APOL2 23780
Affinity Capture-MS Homo sapiens
132 TP53BP1 7158
Affinity Capture-MS Homo sapiens
133 RNF181  
Affinity Capture-MS Homo sapiens
134 Rps6ka3 110651
Affinity Capture-Western Mus musculus
135 MAGEA11  
Biochemical Activity Homo sapiens
136 KIRREL2  
Affinity Capture-MS Homo sapiens
137 HMGCS1 3157
Co-fractionation Homo sapiens
138 TMEM189  
Affinity Capture-MS Homo sapiens
139 MYOG  
Two-hybrid Homo sapiens
140 FERMT2 10979
Co-fractionation Homo sapiens
141 FASN 2194
Affinity Capture-MS Homo sapiens
142 LMNB2 84823
Co-fractionation Homo sapiens
143 MAPKAPK2 9261
PCA Homo sapiens
144 SYT6  
Affinity Capture-MS Homo sapiens
145 ZC3HC1  
Biochemical Activity Homo sapiens
146 MAP3K1 4214
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
147 CIITA  
Affinity Capture-Western Homo sapiens
148 IER3  
Affinity Capture-Western Homo sapiens
149 METTL3  
Affinity Capture-Western Homo sapiens
150 KPNA2 3838
Co-fractionation Homo sapiens
151 PPP2CA 5515
Affinity Capture-Western Homo sapiens
152 DUSP6 1848
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
153 SULT4A1  
Biochemical Activity Homo sapiens
154 PTPN7 5778
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
155 HNF4A  
Biochemical Activity Homo sapiens
156 CDC25C  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
157 MAP2K3 5606
Reconstituted Complex Homo sapiens
158 C1QBP 708
Biochemical Activity Homo sapiens
159 DCUN1D1 54165
Co-fractionation Homo sapiens
160 ID2  
Two-hybrid Homo sapiens
161 MYC  
Reconstituted Complex Homo sapiens
162 RPA3 6119
Proximity Label-MS Homo sapiens
163 CPLX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
165 DHPS 1725
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 PTPDC1  
Affinity Capture-MS Homo sapiens
167 DCC  
Two-hybrid Homo sapiens
168 DUSP9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
169 RAF1 5894
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
170 AMOT 154796
Two-hybrid Homo sapiens
171 EDF1 8721
Affinity Capture-MS Homo sapiens
172 CPXM1  
Two-hybrid Homo sapiens
173 RNF114 55905
Two-hybrid Homo sapiens
174 NUDT21 11051
Affinity Capture-MS Homo sapiens
175 TRPS1  
Affinity Capture-MS Homo sapiens
176 PPME1 51400
Affinity Capture-MS Homo sapiens
177 DCP1A 55802
Two-hybrid Homo sapiens
178 AVPR2  
Affinity Capture-Western Homo sapiens
179 Rara  
Biochemical Activity Mus musculus
180 STUB1 10273
Biochemical Activity Homo sapiens
181 PFKFB1  
Two-hybrid Homo sapiens
182 TBX3 6926
Affinity Capture-MS Homo sapiens
183 TAF6 6878
Affinity Capture-MS Homo sapiens
184 SNCA 6622
Affinity Capture-Western Homo sapiens
185 MAP2K2 5605
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
186 ARRB2 409
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
187 PRKCSH 5589
Affinity Capture-MS Homo sapiens
188 GRN 2896
Affinity Capture-MS Homo sapiens
189 NMD3 51068
Co-fractionation Homo sapiens
190 GMFB 2764
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
191 SIRT6  
Affinity Capture-MS Homo sapiens
192 RALGDS  
Co-localization Homo sapiens
193 Rps6kb1  
Reconstituted Complex Mus musculus
194 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
195 CUEDC1 404093
Affinity Capture-MS Homo sapiens
196 TTC27 55622
Co-fractionation Homo sapiens
197 VPS52 6293
Two-hybrid Homo sapiens
198 ASNS 440
Co-fractionation Homo sapiens
199 HDAC6 10013
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
200 DUSP3 1845
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
201 HADH 3033
Affinity Capture-MS Homo sapiens
202 LGALS3 3958
Affinity Capture-MS Homo sapiens
203 SNCG 6623
Affinity Capture-Western Homo sapiens
204 MKNK1  
Biochemical Activity Homo sapiens
205 RYK 6259
Affinity Capture-MS Homo sapiens
206 RPTOR 57521
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
207 ELK1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
208 INSR 3643
Affinity Capture-Western Homo sapiens
209 CREBBP  
Biochemical Activity Homo sapiens
210 VTA1 51534
Co-fractionation Homo sapiens
211 FKBP2 2286
Two-hybrid Homo sapiens
212 C19orf25  
Affinity Capture-MS Homo sapiens
213 ADAM15 8751
Affinity Capture-Western Homo sapiens
214 GAB2 9846
Biochemical Activity Homo sapiens
215 MAP2K1 5604
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
216 WIF1 11197
Affinity Capture-MS Homo sapiens
217 ILKAP 80895
Co-fractionation Homo sapiens
218 ITGAV 3685
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
219 KHDRBS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 RBM4 5936
Affinity Capture-MS Homo sapiens
221 C10orf88  
Affinity Capture-MS Homo sapiens
222 L3MBTL3  
Two-hybrid Homo sapiens
223 EYA4 2070
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
224 PFKM 5213
Two-hybrid Homo sapiens
225 BAG6 7917
Affinity Capture-MS Homo sapiens
226 ARRB1 408
Biochemical Activity Homo sapiens
227 HSF1  
Affinity Capture-Western Homo sapiens
228 PRKCA 5578
Co-fractionation Homo sapiens
229 ATP1A1 476
Biochemical Activity Homo sapiens
230 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
231 PHF3  
Affinity Capture-MS Homo sapiens
232 DUSP4 1846
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
233 SERBP1 26135
Affinity Capture-MS Homo sapiens
234 ECM1 1893
Affinity Capture-MS Homo sapiens
235 ZBTB42  
Affinity Capture-MS Homo sapiens
236 ATOH1  
Affinity Capture-MS Homo sapiens
237 VIM 7431
Co-fractionation Homo sapiens
238 RBM26 64062
Affinity Capture-MS Homo sapiens
239 CAV1 857
Affinity Capture-Western Homo sapiens
240 GPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 Dusp9  
Two-hybrid Mus musculus
242 FAM133A 286499
Affinity Capture-MS Homo sapiens
243 NPTX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAPK3 is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Activation of the AP-1 family of transcription factors TAS Reactome
Advanced glycosylation endproduct receptor signaling IEA Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Apoptosis TAS Reactome
Apoptotic factor-mediated response TAS Reactome
Axon guidance TAS Reactome
Bacterial Infection Pathways TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress TAS Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence TAS Reactome
Cellular Senescence IEA Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling IEA Reactome
Cytochrome c-mediated apoptotic response TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity TAS Reactome
ERK/MAPK targets TAS Reactome
ERK/MAPK targets IEA Reactome
ERKs are inactivated TAS Reactome
ESR-mediated signaling IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling IEA Reactome
Extra-nuclear estrogen signaling IEA Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
Formation of apoptosome TAS Reactome
Frs2-mediated activation TAS Reactome
G alpha (q) signalling events TAS Reactome
Gastrin-CREB signalling pathway via PKC and MAPK TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway IEA Reactome
Generic Transcription Pathway TAS Reactome
Golgi Cisternae Pericentriolar Stack Reorganization TAS Reactome
GPCR downstream signalling TAS Reactome
Growth hormone receptor signaling TAS Reactome
Hemostasis TAS Reactome
IFNG signaling activates MAPKs TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infection with Mycobacterium tuberculosis TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Insulin receptor signalling cascade TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
Interleukin-17 signaling IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Intrinsic Pathway for Apoptosis TAS Reactome
ISG15 antiviral mechanism TAS Reactome
L1CAM interactions TAS Reactome
Leishmania infection TAS Reactome
Leishmania phagocytosis TAS Reactome
M Phase TAS Reactome
MAP kinase activation TAS Reactome
MAP kinase activation IEA Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases IEA Reactome
MAPK1/MAPK3 signaling TAS Reactome
MAPK3 (ERK1) activation TAS Reactome
MITF-M-regulated melanocyte development TAS Reactome
Mitotic Prophase TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
NCAM signaling for neurite out-growth TAS Reactome
Negative feedback regulation of MAPK pathway TAS Reactome
Negative regulation of FGFR1 signaling TAS Reactome
Negative regulation of FGFR2 signaling TAS Reactome
Negative regulation of FGFR3 signaling TAS Reactome
Negative regulation of FGFR4 signaling TAS Reactome
Negative regulation of MAPK pathway TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nervous system development TAS Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
NPAS4 regulates expression of target genes IEA Reactome
NPAS4 regulates expression of target genes TAS Reactome
Nuclear Events (kinase and transcription factor activation) TAS Reactome
Nuclear Events (kinase and transcription factor activation) IEA Reactome
Nuclear events stimulated by ALK signaling in cancer TAS Reactome
Oncogene Induced Senescence TAS Reactome
Oncogene Induced Senescence IEA Reactome
Oncogenic MAPK signaling TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Post NMDA receptor activation events IEA Reactome
Programmed Cell Death TAS Reactome
Prolonged ERK activation events TAS Reactome
PTEN Regulation TAS Reactome
RAF-independent MAPK1/3 activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
Regulation of HSF1-mediated heat shock response TAS Reactome
Regulation of PTEN gene transcription TAS Reactome
Regulation of the apoptosome activity TAS Reactome
Response of Mtb to phagocytosis TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate NADPH Oxidases TAS Reactome
RHO GTPases Activate WASPs and WAVEs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RSK activation IEA Reactome
RUNX2 regulates bone development IEA Reactome
RUNX2 regulates osteoblast differentiation IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal attenuation TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signal transduction by L1 TAS Reactome
Signaling by Activin TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by LTK in cancer TAS Reactome
Signaling by MAP2K mutants TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by NODAL TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Signalling to ERKs TAS Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TAS Reactome
Spry regulation of FGF signaling TAS Reactome
Suppression of apoptosis TAS Reactome
Thrombin signalling through proteinase activated receptors (PARs) TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades TAS Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer TAS Reactome
Transcriptional and post-translational regulation of MITF-M expression and activity TAS Reactome
Transcriptional Regulation by NPAS4 IEA Reactome
Transcriptional Regulation by NPAS4 TAS Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transmission across Chemical Synapses IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome





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