Gene description for ARHGEF2
Gene name	Rho/Rac guanine nucleotide exchange factor (GEF) 2
Gene symbol	ARHGEF2
Other names/aliases	GEF GEF-H1 GEFH1 LFP40 P40
Species	Homo sapiens
Database cross references - ARHGEF2
ExoCarta	ExoCarta_9181
Entrez Gene	9181
HGNC	682
MIM	607560
UniProt	Q92974
ARHGEF2 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for ARHGEF2

Molecular Function     Rho GTPase binding GO:0017048 IDA     Rho guanyl-nucleotide exchange factor activity GO:0005089 IDA     zinc ion binding GO:0008270 NAS     protein binding GO:0005515 IPI     Rac GTPase binding GO:0048365 IDA     transcription factor binding GO:0008134 ISS     microtubule binding GO:0008017 IDA     Rac guanyl-nucleotide exchange factor activity GO:0030676 IDA Biological Process     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     positive regulation of tumor necrosis factor production GO:0032760 IDA     apoptotic signaling pathway GO:0097190 TAS     small GTPase mediated signal transduction GO:0007264 TAS     positive regulation of interleukin-6 production GO:0032755 IDA     cellular response to muramyl dipeptide GO:0071225 IDA     regulation of small GTPase mediated signal transduction GO:0051056 TAS     cell morphogenesis GO:0000902 IMP     negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219 ISS     positive regulation of GTPase activity GO:0043547 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     regulation of cell proliferation GO:0042127 TAS     regulation of Rho protein signal transduction GO:0035023 NAS     negative regulation of microtubule depolymerization GO:0007026 IMP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISS     innate immune response GO:0045087 IEA     intracellular protein transport GO:0006886 NAS     negative regulation of neurogenesis GO:0050768 IEA     mitotic nuclear division GO:0007067 IEA     actin filament organization GO:0007015 IMP     cellular response to tumor necrosis factor GO:0071356 ISS     cell division GO:0051301 IEA     positive regulation of apoptotic process GO:0043065 TAS     cellular hyperosmotic response GO:0071474 ISS     negative regulation of necroptotic process GO:0060546 ISS     establishment of mitotic spindle orientation GO:0000132 IEA Subcellular Localization     vesicle GO:0031982 IDA     Golgi apparatus GO:0005794 IEA     protein complex GO:0043234 IDA     bicellular tight junction GO:0005923 IEA     cytoplasm GO:0005737 IDA     microtubule GO:0005874 IDA     dendritic shaft GO:0043198 IEA     cytoskeleton GO:0005856 IDA     cytoplasmic membrane-bounded vesicle GO:0016023 IEA     spindle GO:0005819 IEA     ruffle membrane GO:0032587 IDA     focal adhesion GO:0005925 IDA     neuronal cell body GO:0043025 IEA     cytosol GO:0005829 TAS