Gene description for FBXO45
Gene name F-box protein 45
Gene symbol FBXO45
Other names/aliases Fbx45
Species Homo sapiens
 Database cross references - FBXO45
ExoCarta ExoCarta_200933
Entrez Gene 200933
HGNC 29148
MIM 609112
UniProt P0C2W1  
 FBXO45 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FBXO45
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    corticospinal tract morphogenesis GO:0021957 IEA
    neuron migration GO:0001764 IEA
    anterior commissure morphogenesis GO:0021960 IEA
    protein ubiquitination GO:0016567 ISS
    synapse assembly involved in innervation GO:0060386 IEA
    cerebral cortex tangential migration GO:0021800 IEA
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IDA
    cellular response to DNA damage stimulus GO:0006974 IDA
    cerebral cortex radially oriented cell migration GO:0021799 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
Subcellular Localization
    presynaptic membrane GO:0042734 IEA
    postsynaptic membrane GO:0045211 IEA
    cell junction GO:0030054 IEA
    postsynaptic density GO:0014069 IEA
 Experiment description of studies that identified FBXO45 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBXO45
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FBXO45 is involved
No pathways found





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