Gene description for INHBE
Gene name inhibin, beta E
Gene symbol INHBE
Other names/aliases -
Species Homo sapiens
 Database cross references - INHBE
ExoCarta ExoCarta_83729
Vesiclepedia VP_83729
Entrez Gene 83729
HGNC 24029
MIM 612031
UniProt P58166  
 INHBE identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for INHBE
Molecular Function
    cytokine activity GO:0005125 IBA
    hormone activity GO:0005179 IEA
    growth factor activity GO:0008083 IEA
Biological Process
    signal transduction GO:0007165 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified INHBE in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for INHBE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL3  
Affinity Capture-MS Homo sapiens
2 LY6H  
Affinity Capture-MS Homo sapiens
3 C7orf34  
Affinity Capture-MS Homo sapiens
4 WFDC6  
Affinity Capture-MS Homo sapiens
5 FBXO45 200933
Affinity Capture-MS Homo sapiens
6 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MYO1F 4542
Affinity Capture-MS Homo sapiens
8 C1QTNF9B  
Affinity Capture-MS Homo sapiens
9 MYCBP2 23077
Affinity Capture-MS Homo sapiens
10 CELSR1 9620
Affinity Capture-MS Homo sapiens
11 NOTCH2 4853
Affinity Capture-MS Homo sapiens
12 PCDHGB5 56101
Affinity Capture-MS Homo sapiens
13 ADAMTS7  
Affinity Capture-MS Homo sapiens
14 PRMT7  
Affinity Capture-MS Homo sapiens
15 HPN  
Affinity Capture-MS Homo sapiens
16 CPA2  
Affinity Capture-MS Homo sapiens
17 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PDGFRA 5156
Affinity Capture-MS Homo sapiens
19 COLEC10 10584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PTEN 5728
Affinity Capture-MS Homo sapiens
21 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
22 VHL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SHMT2 6472
Affinity Capture-RNA Homo sapiens
24 SPSB2  
Affinity Capture-MS Homo sapiens
25 SCAP  
Affinity Capture-MS Homo sapiens
26 APP 351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 FST 10468
Reconstituted Complex Homo sapiens
28 MANBA 4126
Affinity Capture-MS Homo sapiens
29 VWDE  
Affinity Capture-MS Homo sapiens
30 ERBB2IP 55914
Affinity Capture-MS Homo sapiens
31 F2 2147
Affinity Capture-MS Homo sapiens
32 SCGB2A2  
Affinity Capture-MS Homo sapiens
33 C1orf54  
Affinity Capture-MS Homo sapiens
34 SPRYD3 84926
Affinity Capture-MS Homo sapiens
35 FRAS1 80144
Affinity Capture-MS Homo sapiens
36 TRIB1 10221
Affinity Capture-MS Homo sapiens
37 FAM169A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PCSK9 255738
Affinity Capture-MS Homo sapiens
39 ST14 6768
Affinity Capture-MS Homo sapiens
40 ITFG3 83986
Affinity Capture-MS Homo sapiens
41 ANKRD46 157567
Affinity Capture-MS Homo sapiens
42 PASK  
Affinity Capture-MS Homo sapiens
43 TMPRSS13  
Affinity Capture-MS Homo sapiens
44 UST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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