Gene description for INHBE
Gene name inhibin, beta E
Gene symbol INHBE
Other names/aliases -
Species Homo sapiens
 Database cross references - INHBE
ExoCarta ExoCarta_83729
Vesiclepedia VP_83729
Entrez Gene 83729
HGNC 24029
MIM 612031
UniProt P58166  
 INHBE identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for INHBE
Molecular Function
    transforming growth factor beta receptor binding GO:0005160 IBA
    growth factor activity GO:0008083 IEA
    cytokine activity GO:0005125 IBA
    hormone activity GO:0005179 IEA
Biological Process
    growth GO:0040007 IEA
    regulation of MAPK cascade GO:0043408 IBA
    regulation of apoptotic process GO:0042981 IBA
    cell development GO:0048468 IBA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    SMAD protein signal transduction GO:0060395 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified INHBE in exosomes
1
Experiment ID 497
MISEV standards
✘ EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for INHBE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FST 10468
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which INHBE is involved
PathwayEvidenceSource
Glycoprotein hormones TAS Reactome





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