Gene description for TRIB1
Gene name tribbles pseudokinase 1
Gene symbol TRIB1
Other names/aliases C8FW
Species Homo sapiens
 Database cross references - TRIB1
ExoCarta ExoCarta_10221
Entrez Gene 10221
HGNC 16891
MIM 609461
UniProt Q96RU8  
 TRIB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TRIB1
Molecular Function
    mitogen-activated protein kinase kinase binding GO:0031434 IDA
    ubiquitin protein ligase binding GO:0031625 ISS
    protein kinase activity GO:0004672 TAS
    protein kinase inhibitor activity GO:0004860 IMP
    ATP binding GO:0005524 TAS
    ubiquitin-protein transferase regulator activity GO:0055106 ISS
    transcription factor binding GO:0008134 IPI
Biological Process
    regulation of MAP kinase activity GO:0043405 IDA
    negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 IMP
    protein phosphorylation GO:0006468 TAS
    negative regulation of smooth muscle cell proliferation GO:0048662 IMP
    negative regulation of protein kinase activity GO:0006469 IMP
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    negative regulation of smooth muscle cell migration GO:0014912 IMP
    JNK cascade GO:0007254 IMP
    response to lipopolysaccharide GO:0032496 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TRIB1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TRIB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ALOX12 239
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIB1 is involved
No pathways found

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