Gene description for MALT1
Gene name MALT1 paracaspase
Gene symbol MALT1
Other names/aliases IMD12
MLT
MLT1
Species Homo sapiens
 Database cross references - MALT1
ExoCarta ExoCarta_10892
Vesiclepedia VP_10892
Entrez Gene 10892
HGNC 6819
MIM 604860
UniProt Q9UDY8  
 MALT1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for MALT1
Molecular Function
    protease binding GO:0002020 IEA
    endopeptidase activity GO:0004175 IBA
    endopeptidase activity GO:0004175 IDA
    cysteine-type endopeptidase activity GO:0004197 NAS
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 IDA
    kinase activator activity GO:0019209 IMP
    small molecule binding GO:0036094 EXP
    identical protein binding GO:0042802 IPI
    endopeptidase activator activity GO:0061133 IMP
Biological Process
    B-1 B cell differentiation GO:0001923 IEA
    positive regulation of T cell cytokine production GO:0002726 IMP
    proteolysis GO:0006508 IDA
    defense response GO:0006952 NAS
    response to fungus GO:0009620 IEA
    positive regulation of protein ubiquitination GO:0031398 NAS
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    positive regulation of interleukin-1 beta production GO:0032731 IMP
    positive regulation of interleukin-2 production GO:0032743 IMP
    T cell proliferation GO:0042098 IEA
    B cell activation GO:0042113 IBA
    regulation of apoptotic process GO:0042981 IDA
    negative regulation of apoptotic process GO:0043066 NAS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 HMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    innate immune response GO:0045087 IBA
    T cell receptor signaling pathway GO:0050852 IBA
    T cell receptor signaling pathway GO:0050852 IDA
    regulation of T cell receptor signaling pathway GO:0050856 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    nuclear export GO:0051168 IDA
    proteolysis involved in protein catabolic process GO:0051603 IDA
    positive regulation of T-helper 17 cell differentiation GO:2000321 ISS
Subcellular Localization
    fibrillar center GO:0001650 IDA
    polkadots GO:0002096 IEA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    CBM complex GO:0032449 IDA
    CBM complex GO:0032449 NAS
    protein-containing complex GO:0032991 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified MALT1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MALT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Affinity Capture-Western Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 ADRBK1 156
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
5 USP2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
6 UBE2N 7334
Reconstituted Complex Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 PRKCSH 5589
Affinity Capture-MS Homo sapiens
9 GPS1 2873
Affinity Capture-Western Homo sapiens
10 TRAF2 7186
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 FEM1A  
Two-hybrid Homo sapiens
12 PRMT6  
Two-hybrid Homo sapiens
13 USP9X 8239
Affinity Capture-Western Homo sapiens
14 PRKCD 5580
Affinity Capture-Western Homo sapiens
15 XPO1 7514
Affinity Capture-MS Homo sapiens
16 COPS5 10987
Affinity Capture-Western Homo sapiens
17 CTAG2  
Affinity Capture-MS Homo sapiens
18 HECTD3 79654
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 CSNK1A1 1452
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 NFKBIA  
Affinity Capture-Western Homo sapiens
21 TAB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 FEM1C  
Two-hybrid Homo sapiens
23 TRAF6 7189
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
24 CUL3 8452
Affinity Capture-MS Homo sapiens
25 CARD11  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 LRRC73  
Affinity Capture-MS Homo sapiens
27 BCL10  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 SUV39H1  
Two-hybrid Homo sapiens
29 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 VBP1 7411
Affinity Capture-MS Homo sapiens
31 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 UBE2G2  
Affinity Capture-MS Homo sapiens
33 APEX1 328
Affinity Capture-RNA Homo sapiens
34 S100A6 6277
Affinity Capture-MS Homo sapiens
35 DIABLO 56616
Affinity Capture-Western Homo sapiens
36 PRKCQ 5588
Affinity Capture-Western Homo sapiens
37 UBE2V2 7336
Reconstituted Complex Homo sapiens
38 KDM1A 23028
Two-hybrid Homo sapiens
39 C20orf195  
Affinity Capture-MS Homo sapiens
40 CARM1 10498
Two-hybrid Homo sapiens
41 LAGE3  
Affinity Capture-MS Homo sapiens
42 RNF31 55072
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 KIF23 9493
Affinity Capture-MS Homo sapiens
44 SCGN  
Affinity Capture-MS Homo sapiens
45 RELB  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
46 OTULIN 90268
Affinity Capture-Western Homo sapiens
47 BRD1 23774
Affinity Capture-MS Homo sapiens
48 SHARPIN  
Affinity Capture-Western Homo sapiens
49 MALT1 10892
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
50 TRIB1 10221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 DAB2 1601
Affinity Capture-MS Homo sapiens
52 THTPA  
Affinity Capture-MS Homo sapiens
53 ADRBK1 282682
Reconstituted Complex Bos taurus
Affinity Capture-Western Bos taurus
Reconstituted Complex Bos taurus
54 RBCK1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
55 CAMK2G 818
Affinity Capture-Western Homo sapiens
56 CYLD  
Affinity Capture-Western Homo sapiens
57 NPM1 4869
Proximity Label-MS Homo sapiens
58 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
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