Gene description for MALT1
Gene name MALT1 paracaspase
Gene symbol MALT1
Other names/aliases IMD12
MLT
MLT1
Species Homo sapiens
 Database cross references - MALT1
ExoCarta ExoCarta_10892
Vesiclepedia VP_10892
Entrez Gene 10892
HGNC 6819
MIM 604860
UniProt Q9UDY8  
 MALT1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for MALT1
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-protein transferase activity GO:0004842 IDA
    signal transducer activity GO:0004871 IMP
    kinase activator activity GO:0019209 IMP
    cysteine-type endopeptidase activity GO:0004197 NAS
    protein self-association GO:0043621 IPI
    peptidase activity GO:0008233 IDA
    protease binding GO:0002020 IEA
Biological Process
    activation of NF-kappaB-inducing kinase activity GO:0007250 IMP
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    defense response GO:0006952 NAS
    protein oligomerization GO:0051259 IDA
    protein ubiquitination GO:0016567 IDA
    positive regulation of T cell cytokine production GO:0002726 IMP
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    proteolysis GO:0006508 IDA
    negative regulation of apoptotic process GO:0043066 NAS
    response to fungus GO:0009620 IEA
    T cell receptor signaling pathway GO:0050852 TAS
    positive regulation of T cell activation GO:0050870 IC
    B-1 B cell differentiation GO:0001923 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    T cell proliferation GO:0042098 IEA
    response to molecule of bacterial origin GO:0002237 IEA
    regulation of apoptotic process GO:0042981 IDA
    nuclear export GO:0051168 IDA
    positive regulation of protein ubiquitination GO:0031398 NAS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    innate immune response GO:0045087 TAS
    regulation of T cell receptor signaling pathway GO:0050856 IEA
    positive regulation of interleukin-2 production GO:0032743 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
    nucleus GO:0005634 IDA
    protein complex GO:0043234 IDA
    nucleolus GO:0005730 IDA
    plasma membrane GO:0005886 TAS
    cytoplasm GO:0005737 IDA
    CBM complex GO:0032449 NAS
 Experiment description of studies that identified MALT1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MALT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCL10  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 UBE2G2  
Affinity Capture-MS Homo sapiens
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