Gene description for CAMK2G
Gene name calcium/calmodulin-dependent protein kinase II gamma
Gene symbol CAMK2G
Other names/aliases CAMK
CAMK-II
CAMKG
Species Homo sapiens
 Database cross references - CAMK2G
ExoCarta ExoCarta_818
Vesiclepedia VP_818
Entrez Gene 818
HGNC 1463
MIM 602123
UniProt Q13555  
 CAMK2G identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for CAMK2G
Molecular Function
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA
    calcium-dependent protein serine/threonine phosphatase activity GO:0004723 NAS
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 NAS
    ATP binding GO:0005524 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    protein serine kinase activity GO:0106310 IEA
Biological Process
    nervous system development GO:0007399 IEA
    regulation of neuron projection development GO:0010975 IBA
    regulation of neuron projection development GO:0010975 IMP
    regulation of skeletal muscle adaptation GO:0014733 TAS
    insulin secretion GO:0030073 NAS
    cell differentiation GO:0030154 IEA
    regulation of neuronal synaptic plasticity GO:0048168 IBA
    regulation of calcium ion transport GO:0051924 TAS
    regulation of protein localization to plasma membrane GO:1903076 IBA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    calcium- and calmodulin-dependent protein kinase complex GO:0005954 IDA
    postsynaptic density GO:0014069 IBA
    membrane GO:0016020 HDA
    endocytic vesicle membrane GO:0030666 TAS
    sarcoplasmic reticulum membrane GO:0033017 IEA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified CAMK2G in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CAMK2G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mtx1  
Affinity Capture-MS Mus musculus
2 CALML3 810
Affinity Capture-MS Homo sapiens
3 TBC1D4  
Affinity Capture-MS Homo sapiens
4 ACAA1 30
Co-fractionation Homo sapiens
5 YWHAE 7531
Affinity Capture-MS Homo sapiens
6 C12orf74  
Affinity Capture-MS Homo sapiens
7 Calml3  
Affinity Capture-MS Mus musculus
8 RRAD 6236
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
9 DBN1 1627
Affinity Capture-MS Homo sapiens
10 FAM163B  
Affinity Capture-MS Homo sapiens
11 MAP10  
Affinity Capture-MS Homo sapiens
12 CALM1 801
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 RPUSD4 84881
Affinity Capture-MS Homo sapiens
14 Csk 12988
Affinity Capture-MS Mus musculus
15 ASXL1  
Affinity Capture-MS Homo sapiens
16 SBDS 51119
Co-fractionation Homo sapiens
17 TMEM200A 114801
Affinity Capture-MS Homo sapiens
18 ITPR3 3710
Affinity Capture-MS Homo sapiens
19 APEX1 328
Affinity Capture-RNA Homo sapiens
20 CAPZB 832
Affinity Capture-MS Homo sapiens
21 GOLGA6L2  
Affinity Capture-MS Homo sapiens
22 Lrrc7  
Two-hybrid Rattus norvegicus
23 BCL10  
Affinity Capture-Western Homo sapiens
24 KIF23 9493
Affinity Capture-MS Homo sapiens
25 ESRRG  
Two-hybrid Homo sapiens
26 IQGAP1 8826
Affinity Capture-MS Homo sapiens
27 CALM3 808
Affinity Capture-MS Homo sapiens
28 GUSBP5  
Affinity Capture-MS Homo sapiens
29 PUSL1  
Affinity Capture-MS Homo sapiens
30 CAMK2B 816
Affinity Capture-MS Homo sapiens
31 DUS1L 64118
Two-hybrid Homo sapiens
32 POLR1E  
Proximity Label-MS Homo sapiens
33 RBM42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NPAS1  
Affinity Capture-MS Homo sapiens
35 PRNP 5621
Affinity Capture-MS Homo sapiens
36 YWHAB 7529
Affinity Capture-MS Homo sapiens
37 CALM2 805
Affinity Capture-MS Homo sapiens
38 CAMK2A 815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 DNAL4  
Affinity Capture-MS Homo sapiens
40 B4GALT2  
Affinity Capture-MS Homo sapiens
41 NDUFA8 4702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 UBE2I 7329
Two-hybrid Homo sapiens
43 CARM1 10498
Affinity Capture-MS Homo sapiens
44 TNPO2 30000
Two-hybrid Homo sapiens
45 SMAD3 4088
Co-localization Homo sapiens
46 GRIN1 2902
Biochemical Activity Homo sapiens
47 SMAD2 4087
Biochemical Activity Homo sapiens
48 ARRDC3 57561
Affinity Capture-MS Homo sapiens
49 MALT1 10892
Affinity Capture-Western Homo sapiens
50 THOC2 57187
Affinity Capture-MS Homo sapiens
51 MRPL11 65003
Two-hybrid Homo sapiens
52 SIVA1  
Affinity Capture-Western Homo sapiens
53 CEBPA  
Protein-peptide Homo sapiens
54 TIRAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 UBXN6 80700
Affinity Capture-MS Homo sapiens
56 DACT2  
Affinity Capture-MS Homo sapiens
57 IGBP1 3476
Affinity Capture-MS Homo sapiens
58 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 YWHAZ 7534
Affinity Capture-MS Homo sapiens
60 SNAPC4  
Affinity Capture-MS Homo sapiens
61 CUL3 8452
Affinity Capture-MS Homo sapiens
62 NR3C1 2908
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CTTN 2017
Affinity Capture-MS Homo sapiens
64 ERCC4  
Affinity Capture-MS Homo sapiens
65 MAP3K7  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
66 ECHS1 1892
Affinity Capture-MS Homo sapiens
67 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
68 NXF1 10482
Two-hybrid Homo sapiens
69 FKBP5 2289
Affinity Capture-MS Homo sapiens
70 ARHGAP25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 ARHGAP29 9411
Affinity Capture-MS Homo sapiens
72 MYC  
Dosage Lethality Homo sapiens
73 RPA3 6119
Proximity Label-MS Homo sapiens
74 GRIN2B  
Biochemical Activity Homo sapiens
75 DNM1L 10059
Cross-Linking-MS (XL-MS) Homo sapiens
76 USP19 10869
Affinity Capture-MS Homo sapiens
77 STMN1 3925
Biochemical Activity Homo sapiens
78 Jup 16480
Affinity Capture-MS Mus musculus
79 KRTAP6-1  
Two-hybrid Homo sapiens
80 KRAS 3845
Negative Genetic Homo sapiens
81 BAIAP2 10458
Affinity Capture-MS Homo sapiens
82 CAMK2G 818
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
83 KRTAP6-3  
Two-hybrid Homo sapiens
84 TTC5  
Two-hybrid Homo sapiens
85 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
86 FASN 2194
Positive Genetic Homo sapiens
87 NUTF2 10204
Two-hybrid Homo sapiens
88 SIRT6  
Affinity Capture-MS Homo sapiens
89 SHISA6  
Affinity Capture-MS Homo sapiens
90 KRTAP19-3  
Two-hybrid Homo sapiens
91 TUBG1 7283
Affinity Capture-MS Homo sapiens
92 MCM5 4174
Affinity Capture-MS Homo sapiens
93 KLHL26  
Affinity Capture-MS Homo sapiens
94 Myo1c 17913
Affinity Capture-MS Mus musculus
95 CDC37 11140
Two-hybrid Homo sapiens
96 CAPZA2 830
Affinity Capture-MS Homo sapiens
97 SMAD4  
Biochemical Activity Homo sapiens
98 RCHY1  
Biochemical Activity Homo sapiens
99 ZNF488  
Affinity Capture-MS Homo sapiens
100 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
101 MAGEA9  
Affinity Capture-MS Homo sapiens
102 DDX11 1663
Co-fractionation Homo sapiens
103 PDLIM5 10611
Co-fractionation Homo sapiens
104 BECN1 8678
Affinity Capture-Western Homo sapiens
105 INF2 64423
Affinity Capture-MS Homo sapiens
106 SYNPO 11346
Affinity Capture-MS Homo sapiens
107 FLNA 2316
Co-localization Homo sapiens
108 KANK2 25959
Two-hybrid Homo sapiens
109 CAMK2D 817
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 Ufl1  
Affinity Capture-MS Mus musculus
111 C9orf72  
Affinity Capture-MS Homo sapiens
112 CCT8L2  
Affinity Capture-MS Homo sapiens
113 STRBP 55342
Two-hybrid Homo sapiens
114 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CAMK2G is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Activation of NMDA receptors and postsynaptic events TAS Reactome
Assembly and cell surface presentation of NMDA receptors IEA Reactome
Ca-dependent events IEA Reactome
Calmodulin induced events IEA Reactome
CaM pathway IEA Reactome
CaMK IV-mediated phosphorylation of CREB IEA Reactome
Cardiac conduction TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling IEA Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
DAG and IP3 signaling IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
G alpha (i) signalling events IEA Reactome
G-protein mediated events IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity TAS Reactome
GPCR downstream signalling IEA Reactome
HSF1-dependent transactivation TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Ion channel transport TAS Reactome
Ion homeostasis TAS Reactome
Ion transport by P-type ATPases TAS Reactome
Long-term potentiation IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Muscle contraction TAS Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission IEA Reactome
Neuronal System IEA Reactome
Neuronal System TAS Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission TAS Reactome
Oncogenic MAPK signaling TAS Reactome
Opioid Signalling IEA Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Phase 0 - rapid depolarisation TAS Reactome
PLC beta mediated events IEA Reactome
Post NMDA receptor activation events IEA Reactome
RAF activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Ras activation upon Ca2+ influx through NMDA receptor IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Trafficking of AMPA receptors TAS Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transmission across Chemical Synapses IEA Reactome
Transmission across Chemical Synapses TAS Reactome
Transport of small molecules TAS Reactome
Unblocking of NMDA receptors, glutamate binding and activation TAS Reactome
Unblocking of NMDA receptors, glutamate binding and activation IEA Reactome





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