Gene description for GRIN1
Gene name	glutamate receptor, ionotropic, N-methyl D-aspartate 1
Gene symbol	GRIN1
Other names/aliases	GluN1 MRD8 NMD-R1 NMDA1 NMDAR1 NR1
Species	Homo sapiens
Database cross references - GRIN1
ExoCarta	ExoCarta_2902
Vesiclepedia	VP_2902
Entrez Gene	2902
HGNC	4584
MIM	138249
UniProt	Q05586
GRIN1 identified in sEVs derived from the following tissue/cell type
Plasma	19028452

Gene ontology annotations for GRIN1

Molecular Function     amyloid-beta binding GO:0001540 ISS     NMDA glutamate receptor activity GO:0004972 IBA     NMDA glutamate receptor activity GO:0004972 IDA     NMDA glutamate receptor activity GO:0004972 IDA     NMDA glutamate receptor activity GO:0004972 IMP     NMDA glutamate receptor activity GO:0004972 ISS     NMDA glutamate receptor activity GO:0004972 TAS     calcium channel activity GO:0005262 IDA     calcium ion binding GO:0005509 ISS     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 ISS     ligand-gated monoatomic ion channel activity GO:0015276 IBA     ligand-gated sodium channel activity GO:0015280 IDA     glycine binding GO:0016594 IDA     glycine binding GO:0016594 IMP     glutamate binding GO:0016595 IDA     transmitter-gated monoatomic ion channel activity GO:0022824 ISS     glutamate-gated calcium ion channel activity GO:0022849 IDA     signaling receptor activity GO:0038023 IBA     protein-containing complex binding GO:0044877 ISS Biological Process     monoatomic cation transport GO:0006812 IDA     chemical synaptic transmission GO:0007268 IBA     brain development GO:0007420 NAS     visual learning GO:0008542 ISS     positive regulation of calcium ion transport into cytosol GO:0010524 ISS     propylene metabolic process GO:0018964 ISS     calcium-mediated signaling GO:0019722 IEA     ionotropic glutamate receptor signaling pathway GO:0035235 IBA     ionotropic glutamate receptor signaling pathway GO:0035235 IMP     ionotropic glutamate receptor signaling pathway GO:0035235 ISO     ionotropic glutamate receptor signaling pathway GO:0035235 ISS     sodium ion transmembrane transport GO:0035725 IDA     regulation of membrane potential GO:0042391 IBA     regulation of membrane potential GO:0042391 IDA     response to ethanol GO:0045471 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     regulation of synaptic plasticity GO:0048167 ISS     regulation of synaptic plasticity GO:0048167 NAS     regulation of neuronal synaptic plasticity GO:0048168 NAS     protein heterotetramerization GO:0051290 ISS     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISS     calcium ion homeostasis GO:0055074 ISS     excitatory postsynaptic potential GO:0060079 ISS     calcium ion transmembrane transport GO:0070588 IDA     calcium ion transmembrane import into cytosol GO:0097553 IDA     monoatomic cation transmembrane transport GO:0098655 IDA     monoatomic cation transmembrane transport GO:0098655 ISO     monoatomic cation transmembrane transport GO:0098655 ISS     excitatory chemical synaptic transmission GO:0098976 NAS     positive regulation of reactive oxygen species biosynthetic process GO:1903428 ISS     regulation of monoatomic cation transmembrane transport GO:1904062 ISO     regulation of monoatomic cation transmembrane transport GO:1904062 ISS     cellular response to amyloid-beta GO:1904646 IGI     response to glycine GO:1905429 IDA     positive regulation of excitatory postsynaptic potential GO:2000463 ISO     positive regulation of excitatory postsynaptic potential GO:2000463 ISS Subcellular Localization     cytoplasm GO:0005737 ISS     endoplasmic reticulum membrane GO:0005789 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     synaptic vesicle GO:0008021 ISS     cell surface GO:0009986 ISS     postsynaptic density GO:0014069 ISS     NMDA selective glutamate receptor complex GO:0017146 IBA     NMDA selective glutamate receptor complex GO:0017146 IDA     NMDA selective glutamate receptor complex GO:0017146 ISO     NMDA selective glutamate receptor complex GO:0017146 ISS     NMDA selective glutamate receptor complex GO:0017146 TAS     dendrite GO:0030425 IDA     monoatomic ion channel complex GO:0034702 IDA     neuron projection GO:0043005 IBA     neuron projection GO:0043005 ISS     synaptic cleft GO:0043083 ISS     terminal bouton GO:0043195 ISS     dendritic spine GO:0043197 ISS     synapse GO:0045202 IBA     synapse GO:0045202 ISS     postsynaptic membrane GO:0045211 ISS     postsynaptic membrane GO:0045211 NAS     excitatory synapse GO:0060076 ISS     synaptic membrane GO:0097060 ISS     postsynaptic density membrane GO:0098839 ISS     neurotransmitter receptor complex GO:0098878 IDA