Gene description for GRIN1
Gene name glutamate receptor, ionotropic, N-methyl D-aspartate 1
Gene symbol GRIN1
Other names/aliases GluN1
Species Homo sapiens
 Database cross references - GRIN1
ExoCarta ExoCarta_2902
Entrez Gene 2902
HGNC 4584
MIM 138249
UniProt Q05586  
 GRIN1 identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for GRIN1
Molecular Function
    glycine binding GO:0016594 IMP
    glutamate receptor binding GO:0035254 IEA
    calcium ion binding GO:0005509 ISS
    neurotransmitter binding GO:0042165 ISS
    enzyme binding GO:0019899 IEA
    protein binding GO:0005515 IPI
    extracellular-glutamate-gated ion channel activity GO:0005234 IBA
    calmodulin binding GO:0005516 ISS
    N-methyl-D-aspartate selective glutamate receptor activity GO:0004972 IDA
    voltage-gated cation channel activity GO:0022843 IEA
    calcium channel activity GO:0005262 IDA
    glutamate binding GO:0016595 IDA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    regulation of respiratory gaseous exchange GO:0043576 IEA
    regulation of synapse assembly GO:0051963 IEA
    axon guidance GO:0007411 TAS
    cation transport GO:0006812 IDA
    response to calcium ion GO:0051592 IEA
    regulation of membrane potential GO:0042391 IDA
    ion transmembrane transport GO:0034220 IBA
    cellular response to manganese ion GO:0071287 IEA
    response to fungicide GO:0060992 IEA
    ionotropic glutamate receptor signaling pathway GO:0035235 ISS
    visual learning GO:0008542 ISS
    ephrin receptor signaling pathway GO:0048013 TAS
    cellular calcium ion homeostasis GO:0006874 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    cerebral cortex development GO:0021987 IEA
    conditioned taste aversion GO:0001661 IEA
    regulation of dendrite morphogenesis GO:0048814 IEA
    propylene metabolic process GO:0018964 ISS
    long-term memory GO:0007616 IEA
    pons maturation GO:0021586 IEA
    adult locomotory behavior GO:0008344 IEA
    social behavior GO:0035176 IEA
    respiratory gaseous exchange GO:0007585 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    protein tetramerization GO:0051262 IEA
    prepulse inhibition GO:0060134 IEA
    rhythmic process GO:0048511 IEA
    olfactory learning GO:0008355 IEA
    regulation of axonogenesis GO:0050770 IEA
    synaptic transmission, glutamatergic GO:0035249 IBA
    synaptic transmission GO:0007268 TAS
    response to amphetamine GO:0001975 IEA
    negative regulation of neuron apoptotic process GO:0043524 IEA
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISS
    response to ethanol GO:0045471 IDA
    regulation of excitatory postsynaptic membrane potential GO:0060079 ISS
    regulation of ion transmembrane transport GO:0034765 IEA
    male mating behavior GO:0060179 IEA
    response to morphine GO:0043278 IEA
    regulation of long-term neuronal synaptic plasticity GO:0048169 IEA
    calcium ion homeostasis GO:0055074 ISS
    sensory perception of pain GO:0019233 IEA
    suckling behavior GO:0001967 IEA
Subcellular Localization
    dendrite GO:0030425 IDA
    synaptic cleft GO:0043083 ISS
    cell junction GO:0030054 IEA
    synaptic vesicle GO:0008021 ISS
    endoplasmic reticulum GO:0005783 IEA
    dendritic spine GO:0043197 ISS
    excitatory synapse GO:0060076 ISS
    N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 IDA
    dendrite membrane GO:0032590 IEA
    cell surface GO:0009986 ISS
    postsynaptic membrane GO:0045211 ISS
    plasma membrane GO:0005886 TAS
    synapse GO:0045202 ISS
    neuronal postsynaptic density GO:0097481 IEA
    terminal bouton GO:0043195 ISS
    integral component of plasma membrane GO:0005887 IDA
    postsynaptic density GO:0014069 ISS
    neuron projection GO:0043005 ISS
 Experiment description of studies that identified GRIN1 in exosomes
Experiment ID 44
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for GRIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ND2  
Affinity Capture-Western Homo sapiens
2 GRIN3A  
Affinity Capture-Western Homo sapiens
3 CACNG2  
Co-fractionation Homo sapiens
4 GRIN2A  
Affinity Capture-Western Homo sapiens
5 GRIN2B  
Affinity Capture-Western Homo sapiens
6 GRIN3B  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here