Gene description for GRIN1
Gene name	glutamate receptor, ionotropic, N-methyl D-aspartate 1
Gene symbol	GRIN1
Other names/aliases	GluN1 MRD8 NMD-R1 NMDA1 NMDAR1 NR1
Species	Homo sapiens
Database cross references - GRIN1
ExoCarta	ExoCarta_2902
Entrez Gene	2902
HGNC	4584
MIM	138249
UniProt	Q05586
GRIN1 identified in exosomes derived from the following tissue/cell type
Plasma	19028452

Gene ontology annotations for GRIN1

Molecular Function     glycine binding GO:0016594 IMP     glutamate receptor binding GO:0035254 IEA     calcium ion binding GO:0005509 ISS     neurotransmitter binding GO:0042165 ISS     enzyme binding GO:0019899 IEA     protein binding GO:0005515 IPI     extracellular-glutamate-gated ion channel activity GO:0005234 IBA     calmodulin binding GO:0005516 ISS     N-methyl-D-aspartate selective glutamate receptor activity GO:0004972 IDA     voltage-gated cation channel activity GO:0022843 IEA     calcium channel activity GO:0005262 IDA     glutamate binding GO:0016595 IDA     protein heterodimerization activity GO:0046982 IEA Biological Process     regulation of respiratory gaseous exchange GO:0043576 IEA     regulation of synapse assembly GO:0051963 IEA     axon guidance GO:0007411 TAS     cation transport GO:0006812 IDA     response to calcium ion GO:0051592 IEA     regulation of membrane potential GO:0042391 IDA     ion transmembrane transport GO:0034220 IBA     cellular response to manganese ion GO:0071287 IEA     response to fungicide GO:0060992 IEA     ionotropic glutamate receptor signaling pathway GO:0035235 ISS     visual learning GO:0008542 ISS     ephrin receptor signaling pathway GO:0048013 TAS     cellular calcium ion homeostasis GO:0006874 IEA     calcium ion transmembrane transport GO:0070588 IEA     positive regulation of apoptotic process GO:0043065 IEA     cerebral cortex development GO:0021987 IEA     conditioned taste aversion GO:0001661 IEA     regulation of dendrite morphogenesis GO:0048814 IEA     propylene metabolic process GO:0018964 ISS     long-term memory GO:0007616 IEA     pons maturation GO:0021586 IEA     adult locomotory behavior GO:0008344 IEA     social behavior GO:0035176 IEA     respiratory gaseous exchange GO:0007585 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     protein tetramerization GO:0051262 IEA     prepulse inhibition GO:0060134 IEA     rhythmic process GO:0048511 IEA     olfactory learning GO:0008355 IEA     regulation of axonogenesis GO:0050770 IEA     synaptic transmission, glutamatergic GO:0035249 IBA     synaptic transmission GO:0007268 TAS     response to amphetamine GO:0001975 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISS     response to ethanol GO:0045471 IDA     regulation of excitatory postsynaptic membrane potential GO:0060079 ISS     regulation of ion transmembrane transport GO:0034765 IEA     male mating behavior GO:0060179 IEA     response to morphine GO:0043278 IEA     regulation of long-term neuronal synaptic plasticity GO:0048169 IEA     calcium ion homeostasis GO:0055074 ISS     sensory perception of pain GO:0019233 IEA     suckling behavior GO:0001967 IEA Subcellular Localization     dendrite GO:0030425 IDA     synaptic cleft GO:0043083 ISS     cell junction GO:0030054 IEA     synaptic vesicle GO:0008021 ISS     endoplasmic reticulum GO:0005783 IEA     dendritic spine GO:0043197 ISS     excitatory synapse GO:0060076 ISS     N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 IDA     dendrite membrane GO:0032590 IEA     cell surface GO:0009986 ISS     postsynaptic membrane GO:0045211 ISS     plasma membrane GO:0005886 TAS     synapse GO:0045202 ISS     neuronal postsynaptic density GO:0097481 IEA     terminal bouton GO:0043195 ISS     integral component of plasma membrane GO:0005887 IDA     postsynaptic density GO:0014069 ISS     neuron projection GO:0043005 ISS