Gene description for BDKRB1
Gene name bradykinin receptor B1
Gene symbol BDKRB1
Other names/aliases B1BKR
B1R
BDKRB2
BKB1R
BKR1
BRADYB1
Species Homo sapiens
 Database cross references - BDKRB1
ExoCarta ExoCarta_623
Vesiclepedia VP_623
Entrez Gene 623
HGNC 1029
MIM 600337
UniProt P46663  
 BDKRB1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BDKRB1
Molecular Function
    bradykinin receptor activity GO:0004947 IBA
    bradykinin receptor activity GO:0004947 IDA
    protein binding GO:0005515 IPI
    peptide binding GO:0042277 IEA
Biological Process
    positive regulation of leukocyte migration GO:0002687 IEA
    inflammatory response GO:0006954 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    positive regulation of cytosolic calcium ion concentration GO:0007204 TAS
    response to mechanical stimulus GO:0009612 IEA
    cell migration GO:0016477 IEA
    negative regulation of cell growth GO:0030308 IEA
    response to lipopolysaccharide GO:0032496 IEA
    negative regulation of blood pressure GO:0045776 IEA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified BDKRB1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BDKRB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INSIG1  
Two-hybrid Homo sapiens
2 MBOAT7 79143
Two-hybrid Homo sapiens
3 NAP1L4 4676
Two-hybrid Homo sapiens
4 LAPTM4B  
Two-hybrid Homo sapiens
5 C1orf43 25912
Two-hybrid Homo sapiens
6 TP53 7157
Negative Genetic Homo sapiens
7 CERS1 10715
Two-hybrid Homo sapiens
8 NDFIP1 80762
Two-hybrid Homo sapiens
9 NF2 4771
Two-hybrid Homo sapiens
10 SLC25A28  
Two-hybrid Homo sapiens
11 HHATL  
Two-hybrid Homo sapiens
12 TRAT1 50852
Two-hybrid Homo sapiens
13 LRRC4C  
Two-hybrid Homo sapiens
14 TMEM42  
Two-hybrid Homo sapiens
15 SLC39A14 23516
Two-hybrid Homo sapiens
16 RTN4 57142
Two-hybrid Homo sapiens
17 HTT 3064
Two-hybrid Homo sapiens
18 ZNF22  
Two-hybrid Homo sapiens
19 OAZ2  
Two-hybrid Homo sapiens
20 SLC44A2 57153
Two-hybrid Homo sapiens
21 FAM134B 54463
Two-hybrid Homo sapiens
22 SLC6A8 6535
Two-hybrid Homo sapiens
23 GABBR1  
Two-hybrid Homo sapiens
24 GRIN1 2902
Two-hybrid Homo sapiens
25 HILPDA  
Two-hybrid Homo sapiens
26 UQCRC1 7384
Two-hybrid Homo sapiens
27 MDC1  
Two-hybrid Homo sapiens
28 DNAJB1 3337
Two-hybrid Homo sapiens
29 NAGPA 51172
Two-hybrid Homo sapiens
30 RAE1 8480
Two-hybrid Homo sapiens
31 TMX2 51075
Two-hybrid Homo sapiens
32 TRAM1L1  
Two-hybrid Homo sapiens
View the network image/svg+xml



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