Gene description for FAM134B
Gene name family with sequence similarity 134, member B
Gene symbol FAM134B
Other names/aliases JK-1
JK1
Species Homo sapiens
 Database cross references - FAM134B
ExoCarta ExoCarta_54463
Vesiclepedia VP_54463
Entrez Gene 54463
HGNC 25964
MIM 613114
UniProt Q9H6L5  
 FAM134B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FAM134B
Molecular Function
    protein binding GO:0005515 IPI
    endoplasmic reticulum-autophagosome adaptor activity GO:0140506 IEA
Biological Process
    mitophagy GO:0000423 IEA
    endoplasmic reticulum organization GO:0007029 IEA
    sensory perception of pain GO:0019233 IMP
    collagen catabolic process GO:0030574 IEA
    negative regulation of neuron apoptotic process GO:0043524 IBA
    negative regulation of neuron apoptotic process GO:0043524 IMP
    white fat cell differentiation GO:0050872 IEA
    reticulophagy GO:0061709 IBA
    reticulophagy GO:0061709 IMP
Subcellular Localization
    nucleolus GO:0005730 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    cis-Golgi network GO:0005801 ISS
    nuclear body GO:0016604 IDA
 Experiment description of studies that identified FAM134B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FAM134B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REEP5 7905
Proximity Label-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 MRM1  
Affinity Capture-MS Homo sapiens
4 LAPTM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DNAJC25 548645
Proximity Label-MS Homo sapiens
6 RPN2 6185
Proximity Label-MS Homo sapiens
7 MARCKS 4082
Proximity Label-MS Homo sapiens
8 METTL7A 25840
Proximity Label-MS Homo sapiens
9 RAB9A 9367
Proximity Label-MS Homo sapiens
10 LRRC59 55379
Proximity Label-MS Homo sapiens
11 LMAN1 3998
Proximity Label-MS Homo sapiens
12 KIAA1715 80856
Proximity Label-MS Homo sapiens
13 RAB5A 5868
Proximity Label-MS Homo sapiens
14 BCAP31 10134
Proximity Label-MS Homo sapiens
15 HSD3B7 80270
Proximity Label-MS Homo sapiens
16 STIM1 6786
Proximity Label-MS Homo sapiens
17 GJD3  
Proximity Label-MS Homo sapiens
18 EMD 2010
Proximity Label-MS Homo sapiens
19 FKBP8 23770
Proximity Label-MS Homo sapiens
20 PTPN1 5770
Proximity Label-MS Homo sapiens
21 ARL6IP1 23204
Affinity Capture-MS Homo sapiens
22 ERGIC1 57222
Proximity Label-MS Homo sapiens
23 APP 351
Reconstituted Complex Homo sapiens
24 TCEB3 6924
Cross-Linking-MS (XL-MS) Homo sapiens
25 BDKRB1 623
Two-hybrid Homo sapiens
26 B3GAT1  
Proximity Label-MS Homo sapiens
27 SEC62 7095
Proximity Label-MS Homo sapiens
28 ATP2A1 487
Proximity Label-MS Homo sapiens
29 RAB7A 7879
Proximity Label-MS Homo sapiens
30 RAB11A 8766
Proximity Label-MS Homo sapiens
31 AMFR 267
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
32 RPN1 6184
Proximity Label-MS Homo sapiens
33 DNAJC1 64215
Proximity Label-MS Homo sapiens
34 RAB5C 5878
Proximity Label-MS Homo sapiens
35 STX4 6810
Proximity Label-MS Homo sapiens
36 SSR1 6745
Proximity Label-MS Homo sapiens
37 CKAP4 10970
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ELOVL5 60481
Proximity Label-MS Homo sapiens
39 SEC61B 10952
Proximity Label-MS Homo sapiens
40 MAP1LC3B2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM134B is involved
No pathways found





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