Gene description for SEC62
Gene name SEC62 homolog (S. cerevisiae)
Gene symbol SEC62
Other names/aliases Dtrp1
HTP1
TLOC1
TP-1
Species Homo sapiens
 Database cross references - SEC62
ExoCarta ExoCarta_7095
Vesiclepedia VP_7095
Entrez Gene 7095
HGNC 11846
MIM 602173
UniProt Q99442  
 SEC62 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SEC62
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 TAS
Biological Process
    cotranslational protein targeting to membrane GO:0006613 TAS
    post-translational protein targeting to endoplasmic reticulum membrane GO:0006620 IMP
    post-translational protein targeting to membrane, translocation GO:0031204 IBA
    post-translational protein targeting to membrane, translocation GO:0031204 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    rough endoplasmic reticulum GO:0005791 ISS
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
 Experiment description of studies that identified SEC62 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SEC62
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 HS2ST1 9653
Affinity Capture-MS Homo sapiens
4 ARHGAP1 392
Proximity Label-MS Homo sapiens
5 ZNF24  
Reconstituted Complex Homo sapiens
6 C1orf27 54953
Affinity Capture-MS Homo sapiens
7 SRPRB 58477
Proximity Label-MS Homo sapiens
8 HACD3 51495
Proximity Label-MS Homo sapiens
9 EIF2B2 8892
Affinity Capture-MS Homo sapiens
10 JPH1 56704
Proximity Label-MS Homo sapiens
11 CAND2 23066
Affinity Capture-MS Homo sapiens
12 VMP1 81671
Proximity Label-MS Homo sapiens
13 ATP12A 479
Affinity Capture-MS Homo sapiens
14 C9orf78 51759
Affinity Capture-MS Homo sapiens
15 TYROBP  
Affinity Capture-MS Homo sapiens
16 BTN3A3 10384
Proximity Label-MS Homo sapiens
17 ST7  
Proximity Label-MS Homo sapiens
18 LPCAT1 79888
Proximity Label-MS Homo sapiens
19 KDELR1 10945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TBL2 26608
Proximity Label-MS Homo sapiens
21 PALD1 27143
Proximity Label-MS Homo sapiens
22 MCU 90550
Affinity Capture-MS Homo sapiens
23 LPGAT1 9926
Proximity Label-MS Homo sapiens
24 OSBPL9 114883
Proximity Label-MS Homo sapiens
25 SLC39A11  
Affinity Capture-MS Homo sapiens
26 DGKE  
Proximity Label-MS Homo sapiens
27 ARMCX3 51566
Affinity Capture-MS Homo sapiens
28 TMEM201 199953
Proximity Label-MS Homo sapiens
29 CHMP2B 25978
Proximity Label-MS Homo sapiens
30 SCARB1 949
Proximity Label-MS Homo sapiens
31 USP33  
Proximity Label-MS Homo sapiens
32 BET1 10282
Proximity Label-MS Homo sapiens
33 SLC6A15 55117
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
34 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 FAM177A1 283635
Proximity Label-MS Homo sapiens
36 TFRC 7037
Proximity Label-MS Homo sapiens
37 NOTCH2 4853
Proximity Label-MS Homo sapiens
38 CAMLG 819
Proximity Label-MS Homo sapiens
39 ATP2A2 488
Proximity Label-MS Homo sapiens
40 IPO8 10526
Affinity Capture-MS Homo sapiens
41 SENP2 59343
Proximity Label-MS Homo sapiens
42 FAM114A2  
Proximity Label-MS Homo sapiens
43 TMX1 81542
Proximity Label-MS Homo sapiens
44 GGT7 2686
Proximity Label-MS Homo sapiens
45 P2RY8  
Affinity Capture-MS Homo sapiens
46 COPB1 1315
Affinity Capture-MS Homo sapiens
47 CERS2 29956
Proximity Label-MS Homo sapiens
48 UBXN8  
Proximity Label-MS Homo sapiens
49 CLCC1 23155
Proximity Label-MS Homo sapiens
50 MAN2A2 4122
Affinity Capture-MS Homo sapiens
51 GABARAP 11337
Affinity Capture-MS Homo sapiens
52 VAPB 9217
Proximity Label-MS Homo sapiens
53 OGT 8473
Reconstituted Complex Homo sapiens
54 SAR1B 51128
Proximity Label-MS Homo sapiens
55 GORASP2 26003
Proximity Label-MS Homo sapiens
56 CCDC109B 55013
Affinity Capture-MS Homo sapiens
57 SYNE1 23345
Proximity Label-MS Homo sapiens
58 FRAS1 80144
Proximity Label-MS Homo sapiens
59 SND1 27044
Proximity Label-MS Homo sapiens
60 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
61 REEP5 7905
Proximity Label-MS Homo sapiens
62 TMPO 7112
Proximity Label-MS Homo sapiens
63 ANO6 196527
Proximity Label-MS Homo sapiens
64 AGPAT1 10554
Proximity Label-MS Homo sapiens
65 AHCYL1 10768
Proximity Label-MS Homo sapiens
66 LRRC59 55379
Proximity Label-MS Homo sapiens
67 LMNB1 4001
Proximity Label-MS Homo sapiens
68 CHST8 64377
Affinity Capture-MS Homo sapiens
69 TMED8 283578
Proximity Label-MS Homo sapiens
70 ASIC2  
Affinity Capture-MS Homo sapiens
71 BCAP31 10134
Proximity Label-MS Homo sapiens
72 TMEM199  
Proximity Label-MS Homo sapiens
73 ATP6AP2 10159
Proximity Label-MS Homo sapiens
74 NAP1L3  
Affinity Capture-MS Homo sapiens
75 FKBP8 23770
Proximity Label-MS Homo sapiens
76 AAAS 8086
Proximity Label-MS Homo sapiens
77 WLS 79971
Proximity Label-MS Homo sapiens
78 SNX19  
Proximity Label-MS Homo sapiens
79 ZW10 9183
Proximity Label-MS Homo sapiens
80 SOAT1 6646
Proximity Label-MS Homo sapiens
81 TMED10 10972
Affinity Capture-MS Homo sapiens
82 RPA3 6119
Proximity Label-MS Homo sapiens
83 TMCO1 54499
Proximity Label-MS Homo sapiens
84 RINT1 60561
Proximity Label-MS Homo sapiens
85 COPG2 26958
Affinity Capture-MS Homo sapiens
86 PPAPDC1A  
Affinity Capture-MS Homo sapiens
87 CLPSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 FAM169A  
Proximity Label-MS Homo sapiens
89 EIF2B1 1967
Affinity Capture-MS Homo sapiens
90 PARP16 54956
Proximity Label-MS Homo sapiens
91 HMGCR  
Proximity Label-MS Homo sapiens
92 CHML  
Proximity Label-MS Homo sapiens
93 TMEM57  
Proximity Label-MS Homo sapiens
94 AGPAT9  
Proximity Label-MS Homo sapiens
95 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
96 WWOX 51741
Proximity Label-MS Homo sapiens
97 CIC 23152
Two-hybrid Homo sapiens
98 EMC7 56851
Proximity Label-MS Homo sapiens
99 CLPTM1 1209
Proximity Label-MS Homo sapiens
100 CELSR1 9620
Proximity Label-MS Homo sapiens
101 PTPN2 5771
Proximity Label-MS Homo sapiens
102 ITPR3 3710
Proximity Label-MS Homo sapiens
103 PTDSS1 9791
Proximity Label-MS Homo sapiens
104 CERS5 91012
Affinity Capture-MS Homo sapiens
105 RABL3 285282
Proximity Label-MS Homo sapiens
106 HM13 81502
Proximity Label-MS Homo sapiens
107 NDC1 55706
Proximity Label-MS Homo sapiens
108 RAB11A 8766
Proximity Label-MS Homo sapiens
109 ITPR1 3708
Proximity Label-MS Homo sapiens
110 EI24  
Proximity Label-MS Homo sapiens
111 CISD2 493856
Proximity Label-MS Homo sapiens
112 WFS1 7466
Proximity Label-MS Homo sapiens
113 CWC22 57703
Affinity Capture-MS Homo sapiens
114 PRAF2 11230
Proximity Label-MS Homo sapiens
115 VANGL1 81839
Proximity Label-MS Homo sapiens
116 BRI3BP 140707
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 C2CD2L 9854
Proximity Label-MS Homo sapiens
118 ATL1 51062
Proximity Label-MS Homo sapiens
119 METTL7A 25840
Proximity Label-MS Homo sapiens
120 DHRS7 51635
Proximity Label-MS Homo sapiens
121 MFNG  
Affinity Capture-MS Homo sapiens
122 ARL6IP5 10550
Proximity Label-MS Homo sapiens
123 RPA2 6118
Proximity Label-MS Homo sapiens
124 SPTLC1 10558
Proximity Label-MS Homo sapiens
125 SURF4 6836
Proximity Label-MS Homo sapiens
126 SMPD4 55627
Proximity Label-MS Homo sapiens
127 GOSR2 9570
Proximity Label-MS Homo sapiens
128 NUP160 23279
Proximity Label-MS Homo sapiens
129 SERINC2 347735
Affinity Capture-MS Homo sapiens
130 VANGL2  
Proximity Label-MS Homo sapiens
131 WDR41  
Proximity Label-MS Homo sapiens
132 CYB5B 80777
Proximity Label-MS Homo sapiens
133 ELOVL2  
Proximity Label-MS Homo sapiens
134 B4GALT7 11285
Affinity Capture-MS Homo sapiens
135 ATP2A3 489
Affinity Capture-MS Homo sapiens
136 SUN2 25777
Proximity Label-MS Homo sapiens
137 CANX 821
Proximity Label-MS Homo sapiens
138 EBAG9 9166
Proximity Label-MS Homo sapiens
139 LMAN1 3998
Proximity Label-MS Homo sapiens
140 KIAA1715 80856
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
141 CHMP7 91782
Proximity Label-MS Homo sapiens
142 MIB1 57534
Proximity Label-MS Homo sapiens
143 CORO7-PAM16 100529144
Proximity Label-MS Homo sapiens
144 FUT8 2530
Affinity Capture-MS Homo sapiens
145 FUNDC2 65991
Affinity Capture-MS Homo sapiens
146 COPG1 22820
Affinity Capture-MS Homo sapiens
147 EIF2B5 8893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 SNAP47 116841
Proximity Label-MS Homo sapiens
149 CDKAL1  
Proximity Label-MS Homo sapiens
150 PBXIP1 57326
Proximity Label-MS Homo sapiens
151 YIF1A 10897
Proximity Label-MS Homo sapiens
152 SLC9A1 6548
Proximity Label-MS Homo sapiens
153 TRPM7 54822
Proximity Label-MS Homo sapiens
154 TAPT1 202018
Proximity Label-MS Homo sapiens
155 KCNB2  
Proximity Label-MS Homo sapiens
156 GAPDH 2597
Cross-Linking-MS (XL-MS) Homo sapiens
157 JAG2  
Proximity Label-MS Homo sapiens
158 PREB 10113
Proximity Label-MS Homo sapiens
159 STX5 6811
Proximity Label-MS Homo sapiens
160 TMEM131  
Proximity Label-MS Homo sapiens
161 ANO10 55129
Proximity Label-MS Homo sapiens
162 MYH7B  
Affinity Capture-MS Homo sapiens
163 UFSP2 55325
Affinity Capture-MS Homo sapiens
164 SGPL1 8879
Affinity Capture-MS Homo sapiens
165 CXCR4 7852
Affinity Capture-MS Homo sapiens
166 RPN2 6185
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
167 SCD5  
Proximity Label-MS Homo sapiens
168 EMC8 10328
Proximity Label-MS Homo sapiens
169 ADCY9 115
Proximity Label-MS Homo sapiens
170 ABHD12 26090
Proximity Label-MS Homo sapiens
171 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
172 TAOK2 9344
Proximity Label-MS Homo sapiens
173 SLC3A2 6520
Proximity Label-MS Homo sapiens
174 FAM134B 54463
Proximity Label-MS Homo sapiens
175 VRK2 7444
Proximity Label-MS Homo sapiens
176 PKD2 5311
Proximity Label-MS Homo sapiens
177 DDRGK1 65992
Proximity Label-MS Homo sapiens
178 SLC12A6 9990
Affinity Capture-MS Homo sapiens
179 WDR44 54521
Proximity Label-MS Homo sapiens
180 TMEM209 84928
Proximity Label-MS Homo sapiens
181 VIMP 55829
Proximity Label-MS Homo sapiens
182 LEMD3  
Proximity Label-MS Homo sapiens
183 OSBPL8 114882
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 GRAMD1B  
Proximity Label-MS Homo sapiens
185 HUWE1 10075
Affinity Capture-MS Homo sapiens
186 SUN1 23353
Proximity Label-MS Homo sapiens
187 PLXNB2 23654
Proximity Label-MS Homo sapiens
188 SLC38A2 54407
Proximity Label-MS Homo sapiens
189 TRIM13  
Proximity Label-MS Homo sapiens
190 TMEM9 252839
Proximity Label-MS Homo sapiens
191 XPO6 23214
Affinity Capture-MS Homo sapiens
192 PGRMC1 10857
Proximity Label-MS Homo sapiens
193 TMEM214 54867
Proximity Label-MS Homo sapiens
194 ATP1A3 478
Affinity Capture-MS Homo sapiens
195 PDCL 5082
Proximity Label-MS Homo sapiens
196 FKRP 79147
Affinity Capture-MS Homo sapiens
197 EXTL2 2135
Affinity Capture-MS Homo sapiens
198 NSDHL 50814
Proximity Label-MS Homo sapiens
199 PIGU 128869
Proximity Label-MS Homo sapiens
200 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
201 MMGT1 93380
Proximity Label-MS Homo sapiens
202 AUP1 550
Proximity Label-MS Homo sapiens
203 AP3B2 8120
Affinity Capture-MS Homo sapiens
204 LPCAT2 54947
Proximity Label-MS Homo sapiens
205 PLD3 23646
Proximity Label-MS Homo sapiens
206 ATP1A1 476
Proximity Label-MS Homo sapiens
207 TMEM109 79073
Proximity Label-MS Homo sapiens
208 NCEH1 57552
Affinity Capture-MS Homo sapiens
209 IGF2R 3482
Proximity Label-MS Homo sapiens
210 GOLM1 51280
Affinity Capture-MS Homo sapiens
211 CNR2  
Affinity Capture-MS Homo sapiens
212 CKAP4 10970
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
213 ANKRD46 157567
Affinity Capture-MS Homo sapiens
214 AGPAT2  
Affinity Capture-MS Homo sapiens
215 ATP13A1 57130
Proximity Label-MS Homo sapiens
216 DPY19L1 23333
Proximity Label-MS Homo sapiens
217 GABARAPL1 23710
Affinity Capture-MS Homo sapiens
218 NUPL2 11097
Proximity Label-MS Homo sapiens
219 SUCO  
Proximity Label-MS Homo sapiens
220 CLCN7 1186
Proximity Label-MS Homo sapiens
221 VAMP2 6844
Proximity Label-MS Homo sapiens
222 PRKCD 5580
Proximity Label-MS Homo sapiens
223 TMED4 222068
Affinity Capture-MS Homo sapiens
224 AKAP11 11215
Proximity Label-MS Homo sapiens
225 NBAS 51594
Proximity Label-MS Homo sapiens
226 TOX3  
Proximity Label-MS Homo sapiens
227 SYNE2 23224
Proximity Label-MS Homo sapiens
228 PTPN1 5770
Proximity Label-MS Homo sapiens
229 APBB1  
Proximity Label-MS Homo sapiens
230 RTN4 57142
Affinity Capture-MS Homo sapiens