Gene description for TRPM4
Gene name transient receptor potential cation channel, subfamily M, member 4
Gene symbol TRPM4
Other names/aliases PFHB1B
TRPM4B
Species Homo sapiens
 Database cross references - TRPM4
ExoCarta ExoCarta_54795
Entrez Gene 54795
HGNC 17993
MIM 606936
UniProt Q8TD43  
 TRPM4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TRPM4
Molecular Function
    calcium channel activity GO:0005262 IEA
    ATP binding GO:0005524 IEA
    calcium activated cation channel activity GO:0005227 ISS
    calmodulin binding GO:0005516 IEA
Biological Process
    regulation of membrane potential GO:0042391 IEA
    cardiac conduction GO:0061337 IEA
    protein sumoylation GO:0016925 IDA
    dendritic cell chemotaxis GO:0002407 ISS
    ion transmembrane transport GO:0034220 TAS
    transmembrane transport GO:0055085 TAS
    vasoconstriction GO:0042310 IEA
    positive regulation of cell proliferation GO:0008284 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IDA
    regulation of T cell cytokine production GO:0002724 IDA
    calcium ion transmembrane transport GO:0070588 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    endoplasmic reticulum GO:0005783 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified TRPM4 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRPM4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRPM4 is involved
PathwayEvidenceSource
TRP channels TAS Reactome





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