Gene description for LGALS9
Gene name lectin, galactoside-binding, soluble, 9
Gene symbol LGALS9
Other names/aliases HUAT
LGALS9A
Species Homo sapiens
 Database cross references - LGALS9
ExoCarta ExoCarta_3965
Vesiclepedia VP_3965
Entrez Gene 3965
HGNC 6570
MIM 601879
UniProt O00182  
 LGALS9 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LGALS9
Molecular Function
    protein binding GO:0005515 IPI
    galactose binding GO:0005534 TAS
    galactoside binding GO:0016936 IBA
    enzyme binding GO:0019899 IPI
    carbohydrate binding GO:0030246 IBA
    carbohydrate binding GO:0030246 IDA
    disaccharide binding GO:0048030 IMP
Biological Process
    natural killer cell tolerance induction GO:0002519 IMP
    chemotaxis GO:0006935 IEA
    inflammatory response GO:0006954 IDA
    female pregnancy GO:0007565 IDA
    positive regulation of gene expression GO:0010628 IBA
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of gene expression GO:0010629 IDA
    negative regulation of gene expression GO:0010629 IMP
    response to lipopolysaccharide GO:0032496 IMP
    regulation of interleukin-4 production GO:0032673 IDA
    regulation of interleukin-5 production GO:0032674 IDA
    negative regulation of chemokine production GO:0032682 IMP
    negative regulation of type II interferon production GO:0032689 IBA
    negative regulation of type II interferon production GO:0032689 IDA
    negative regulation of tumor necrosis factor production GO:0032720 IMP
    positive regulation of type II interferon production GO:0032729 IDA
    positive regulation of interleukin-1 beta production GO:0032731 IDA
    positive regulation of interleukin-10 production GO:0032733 IDA
    positive regulation of interleukin-12 production GO:0032735 IMP
    positive regulation of interleukin-13 production GO:0032736 IDA
    positive regulation of interleukin-4 production GO:0032753 IDA
    positive regulation of interleukin-4 production GO:0032753 IMP
    positive regulation of interleukin-6 production GO:0032755 IMP
    positive regulation of interleukin-8 production GO:0032757 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response GO:0032834 IDA
    toll-like receptor 2 signaling pathway GO:0034134 IDA
    toll-like receptor 4 signaling pathway GO:0034142 IDA
    p38MAPK cascade GO:0038066 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 HMP
    negative regulation of mast cell degranulation GO:0043305 IMP
    negative regulation of natural killer cell mediated cytotoxicity GO:0045953 IDA
    negative regulation of activated T cell proliferation GO:0046007 IMP
    positive regulation of viral entry into host cell GO:0046598 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    maternal process involved in female pregnancy GO:0060135 IDA
    positive regulation of activated T cell autonomous cell death GO:0070241 IDA
    ERK1 and ERK2 cascade GO:0070371 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    response to interleukin-1 GO:0070555 IDA
    cellular response to type II interferon GO:0071346 IDA
    positive regulation of transforming growth factor beta production GO:0071636 IDA
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 IMP
    mature conventional dendritic cell differentiation GO:0097029 IMP
    cellular response to virus GO:0098586 IMP
    regulation of p38MAPK cascade GO:1900744 IMP
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IMP
    positive regulation of dendritic cell chemotaxis GO:2000510 IMP
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 IBA
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 IDA
    positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 IDA
    positive regulation of dendritic cell apoptotic process GO:2000670 IDA
    positive regulation of cysteine-type endopeptidase activity GO:2001056 IMP
    positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001190 IDA
    positive regulation of dendritic cell differentiation GO:2001200 IMP
Subcellular Localization
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified LGALS9 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LGALS9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PTPRG 5793
Affinity Capture-MS Homo sapiens
3 SLC29A1 2030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ENPP4 22875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MFAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MAN2B1 4125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC15A4 121260
Affinity Capture-MS Homo sapiens
8 SORL1 6653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ATG9A 79065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LGALS9C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PBK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SLC23A2 9962
Affinity Capture-MS Homo sapiens
13 LNPEP 4012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SLC12A2 6558
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PTPN11 5781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SLC38A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LRP1 4035
Affinity Capture-MS Homo sapiens
18 LAMC1 3915
Affinity Capture-MS Homo sapiens
19 SLC38A5 92745
Affinity Capture-MS Homo sapiens
20 TRPM4 54795
Affinity Capture-MS Homo sapiens
21 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
22 USP39 10713
Co-fractionation Homo sapiens
23 SIGIRR 59307
Affinity Capture-MS Homo sapiens
24 NID1 4811
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CD109 135228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CD276 80381
Affinity Capture-MS Homo sapiens
27 ABCA2 20
Affinity Capture-MS Homo sapiens
28 RRAGB 10325
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ITGA4 3676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PDIA6 10130
Reconstituted Complex Homo sapiens
31 ATG16L1 55054
Affinity Capture-MS Homo sapiens
32 ALCAM 214
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ABCC2 1244
Affinity Capture-MS Homo sapiens
34 ATP13A3 79572
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SLC12A7 10723
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LUM 4060
Affinity Capture-MS Homo sapiens
37 ABCC5 10057
Affinity Capture-MS Homo sapiens
38 SLC30A1 7779
Affinity Capture-MS Homo sapiens
39 SEZ6L2 26470
Affinity Capture-MS Homo sapiens
40 MRC2 9902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SLC1A3 6507
Affinity Capture-MS Homo sapiens
42 SLC1A5 6510
Affinity Capture-MS Homo sapiens
43 TMEM63B 55362
Affinity Capture-MS Homo sapiens
44 DAG1 1605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DAZAP2  
Two-hybrid Homo sapiens
46 FBLN1 2192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SLC5A6 8884
Affinity Capture-MS Homo sapiens
48 CLCN3 1182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 TSPAN3 10099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 IFNA5  
Affinity Capture-MS Homo sapiens
51 ACP2 53
Affinity Capture-MS Homo sapiens
52 CSPG4 1464
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RRAGC 64121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SLC7A2 6542
Affinity Capture-MS Homo sapiens
55 P4HB 5034
Reconstituted Complex Homo sapiens
56 RNF13 11342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
57 SLC12A4 6560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CD63 967
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SLC12A9 56996
Affinity Capture-MS Homo sapiens
60 SLC7A1 6541
Affinity Capture-MS Homo sapiens
61 SLC4A7 9497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 NID2 22795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CD58 965
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ANO6 196527
Affinity Capture-MS Homo sapiens
65 SGPL1 8879
Affinity Capture-MS Homo sapiens
66 CLN3 1201
Affinity Capture-MS Homo sapiens
67 PPAP2C 8612
Affinity Capture-MS Homo sapiens
68 ATP2B1 490
Affinity Capture-MS Homo sapiens
69 NPTN 27020
Affinity Capture-MS Homo sapiens
70 CTNNB1 1499
Affinity Capture-MS Homo sapiens
71 PTPRA 5786
Affinity Capture-MS Homo sapiens
72 SLC26A2 1836
Affinity Capture-MS Homo sapiens
73 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 PDIA3 2923
Reconstituted Complex Homo sapiens
75 LGALS9B 284194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 NAGLU 4669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 LAMA1 284217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 ECE1 1889
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 FN1 2335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 SUSD5 26032
Affinity Capture-MS Homo sapiens
81 PTPRK 5796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 SLC44A2 57153
Affinity Capture-MS Homo sapiens
83 IGSF3 3321
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 SLC6A6 6533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ABCC1 4363
Affinity Capture-MS Homo sapiens
86 MPZL1 9019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 KCNN4 3783
Affinity Capture-MS Homo sapiens
88 MET 4233
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 ZER1 10444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PVR 5817
Affinity Capture-MS Homo sapiens
91 SLC12A6 9990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 LAMA4 3910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 LGALS8 3964
Affinity Capture-MS Homo sapiens
94 NTSR1  
Affinity Capture-MS Homo sapiens
95 PODXL 5420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 SLC17A5 26503
Affinity Capture-MS Homo sapiens
97 ATP7A 538
Affinity Capture-MS Homo sapiens
98 SLC9A6 10479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 TMEM63A 9725
Affinity Capture-MS Homo sapiens
100 KRTAP6-3  
Two-hybrid Homo sapiens
101 DNAJC13 23317
Affinity Capture-MS Homo sapiens
102 LAMB1 3912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 KIAA1549  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ITGA5 3678
Affinity Capture-MS Homo sapiens
105 COLEC12 81035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 RSAD2  
Affinity Capture-Western Homo sapiens
107 ATP2B4 493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 JUP 3728
Affinity Capture-MS Homo sapiens
109 PIEZO1 9780
Affinity Capture-MS Homo sapiens
110 PCDH9  
Affinity Capture-MS Homo sapiens
111 OSTM1 28962
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 PLXNA1 5361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 CD47 961
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 ABCC4 10257
Affinity Capture-MS Homo sapiens
116 SQSTM1 8878
Affinity Capture-Western Homo sapiens
117 INSR 3643
Affinity Capture-MS Homo sapiens
118 KIAA0319L 79932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 LPAR2 9170
Affinity Capture-MS Homo sapiens
120 C2CD5 9847
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 PTPRJ 5795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 CD44 960
Affinity Capture-MS Homo sapiens
123 ATP11C 286410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 SLC1A1 6505
Affinity Capture-MS Homo sapiens
125 PTGFRN 5738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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