Gene description for SLC7A2
Gene name solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Gene symbol SLC7A2
Other names/aliases ATRC2
CAT2
HCAT2
Species Homo sapiens
 Database cross references - SLC7A2
ExoCarta ExoCarta_6542
Entrez Gene 6542
HGNC 11060
MIM 601872
UniProt P52569  
 SLC7A2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC7A2
Molecular Function
    high-affinity arginine transmembrane transporter activity GO:0005289 IEA
    antiporter activity GO:0015297 IBA
    high-affinity lysine transmembrane transporter activity GO:0005292 IEA
    arginine transmembrane transporter activity GO:0015181 IBA
    L-lysine transmembrane transporter activity GO:0015189 IBA
    high-affinity L-ornithine transmembrane transporter activity GO:0097627 IEA
    L-ornithine transmembrane transporter activity GO:0000064 IBA
    low-affinity L-arginine transmembrane transporter activity GO:0097626 IEA
    basic amino acid transmembrane transporter activity GO:0015174 TAS
Biological Process
    nitric oxide biosynthetic process GO:0006809 IEA
    transport GO:0006810 TAS
    L-ornithine import across plasma membrane GO:0097640 IEA
    L-lysine import across plasma membrane GO:0097639 IEA
    transmembrane transport GO:0055085 TAS
    amino acid transport GO:0006865 TAS
    L-ornithine transmembrane transport GO:1903352 IBA
    L-lysine transmembrane transport GO:1903401 IBA
    regulation of inflammatory response GO:0050727 IEA
    nitric oxide production involved in inflammatory response GO:0002537 IEA
    L-arginine import across plasma membrane GO:0097638 IBA
    ion transport GO:0006811 TAS
    macrophage activation GO:0042116 IEA
    cellular amino acid metabolic process GO:0006520 TAS
    regulation of macrophage activation GO:0043030 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
 Experiment description of studies that identified SLC7A2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC7A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC7A2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here