Gene description for CD40
Gene name CD40 molecule, TNF receptor superfamily member 5
Gene symbol CD40
Other names/aliases Bp50
CDW40
TNFRSF5
p50
Species Homo sapiens
 Database cross references - CD40
ExoCarta ExoCarta_958
Vesiclepedia VP_958
Entrez Gene 958
HGNC 11919
MIM 109535
UniProt P25942  
 CD40 identified in exosomes derived from the following tissue/cell type
B cells 17641064    
B cells 20458337    
B cells 20458337    
Dendritic cells 14582906    
 Gene ontology annotations for CD40
Molecular Function
    antigen binding GO:0003823 IEA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    protein domain specific binding GO:0019904 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    signaling receptor activity GO:0038023 IDA
Biological Process
    immune response-regulating cell surface receptor signaling pathway GO:0002768 IBA
    intracellular calcium ion homeostasis GO:0006874 IMP
    inflammatory response GO:0006954 TAS
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IMP
    B cell mediated immunity GO:0019724 IEA
    CD40 signaling pathway GO:0023035 IDA
    CD40 signaling pathway GO:0023035 IMP
    platelet activation GO:0030168 NAS
    positive regulation of B cell proliferation GO:0030890 IEA
    positive regulation of interleukin-12 production GO:0032735 IEA
    response to cobalamin GO:0033590 IEA
    response to type II interferon GO:0034341 IEA
    cellular response to erythropoietin GO:0036018 IEA
    B cell proliferation GO:0042100 NAS
    B cell activation GO:0042113 IBA
    defense response to protozoan GO:0042832 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    positive regulation of MAPK cascade GO:0043410 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IEA
    positive regulation of blood vessel endothelial cell migration GO:0043536 IMP
    positive regulation of angiogenesis GO:0045766 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of isotype switching to IgG isotypes GO:0048304 IEA
    defense response to virus GO:0051607 IEA
    protein-containing complex assembly GO:0065003 TAS
    cellular response to lipopolysaccharide GO:0071222 IEA
    cellular response to mechanical stimulus GO:0071260 IEP
    cellular response to interleukin-1 GO:0071347 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    positive regulation of protein kinase C signaling GO:0090037 IMP
    positive regulation of interleukin-4-mediated signaling pathway GO:1902216 IGI
    positive regulation of endothelial cell apoptotic process GO:2000353 IDA
Subcellular Localization
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 HDA
    CD40 receptor complex GO:0035631 IBA
    CD40 receptor complex GO:0035631 ISS
    neuronal cell body GO:0043025 IEA
    varicosity GO:0043196 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CD40 in exosomes
1
Experiment ID 47
MISEV standards
Biophysical techniques
CD81|CD86
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method FACS
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample B cells
Sample name B cells
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study FACS
2
Experiment ID 79
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 80
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 50
MISEV standards
EM|IEM
Biophysical techniques
CD63|CD87
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method FACS
PubMed ID 14582906    
Organism Homo sapiens
Experiment description Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid.
Authors "Admyre C, Grunewald J, Thyberg J, Gripenback S, Tornling G, Eklund A, Scheynius A, Gabrielsson S"
Journal name ERJ
Publication year 2003
Sample Dendritic cells
Sample name Monocyte-derived dendritic cells
Isolation/purification methods Differential centrifugation
Immunobeads (EpCAM)
Flotation density -
Molecules identified in the study Protein
Methods used in the study FACS
Immunoelectron Microscopy
 Protein-protein interactions for CD40
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Affinity Capture-MS Homo sapiens
2 NCOA6  
Reconstituted Complex Homo sapiens
3 CMTM6 54918
Affinity Capture-MS Homo sapiens
4 ORC4  
Affinity Capture-MS Homo sapiens
5 TRAF4 9618
Affinity Capture-Western Homo sapiens
6 TNPO1 3842
Affinity Capture-MS Homo sapiens
7 EIF2B2 8892
Affinity Capture-MS Homo sapiens
8 TMEM147 10430
Two-hybrid Homo sapiens
9 DEFB121  
Two-hybrid Homo sapiens
10 TTI1 9675
Affinity Capture-MS Homo sapiens
11 MFSD5  
Two-hybrid Homo sapiens
12 GEMIN8 54960
Affinity Capture-MS Homo sapiens
13 CSE1L 1434
Affinity Capture-MS Homo sapiens
14 COG2 22796
Affinity Capture-MS Homo sapiens
15 LTN1 26046
Affinity Capture-MS Homo sapiens
16 GCN1L1 10985
Affinity Capture-MS Homo sapiens
17 C1orf112  
Affinity Capture-MS Homo sapiens
18 NUP160 23279
Affinity Capture-MS Homo sapiens
19 SMN2 6607
Affinity Capture-MS Homo sapiens
20 MON2 23041
Affinity Capture-MS Homo sapiens
21 SLC39A11  
Affinity Capture-MS Homo sapiens
22 RNF219  
Affinity Capture-MS Homo sapiens
23 NBEAL2 23218
Affinity Capture-MS Homo sapiens
24 TDP2 51567
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
25 FBL 2091
Affinity Capture-MS Homo sapiens
26 ATP2A3 489
Affinity Capture-MS Homo sapiens
27 IPO8 10526
Affinity Capture-MS Homo sapiens
28 FAF1 11124
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
29 MLST8 64223
Affinity Capture-MS Homo sapiens
30 RIPK2  
Affinity Capture-Western Homo sapiens
31 CALR 811
Affinity Capture-MS Homo sapiens
32 TMEM107 84314
Two-hybrid Homo sapiens
33 EXOC7 23265
Affinity Capture-MS Homo sapiens
34 EXOC5 10640
Affinity Capture-MS Homo sapiens
35 RBPJ 3516
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
36 KIF14 9928
Affinity Capture-MS Homo sapiens
37 INSIG2  
Two-hybrid Homo sapiens
38 HEATR1 55127
Affinity Capture-MS Homo sapiens
39 GEMIN5 25929
Affinity Capture-MS Homo sapiens
40 IPO11 51194
Affinity Capture-MS Homo sapiens
41 RNF213 57674
Affinity Capture-MS Homo sapiens
42 RFC5 5985
Affinity Capture-MS Homo sapiens
43 REEP4  
Affinity Capture-MS Homo sapiens
44 XPO6 23214
Affinity Capture-MS Homo sapiens
45 EIF2B5 8893
Affinity Capture-MS Homo sapiens
46 CBL 867
Affinity Capture-Western Homo sapiens
47 TLCD1  
Two-hybrid Homo sapiens
48 DIABLO 56616
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
49 TNPO2 30000
Affinity Capture-MS Homo sapiens
50 SLC7A2 6542
Affinity Capture-MS Homo sapiens
51 COG3 83548
Affinity Capture-MS Homo sapiens
52 SLC30A3  
Two-hybrid Homo sapiens
53 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 COG5 10466
Affinity Capture-MS Homo sapiens
55 COG4 25839
Affinity Capture-MS Homo sapiens
56 STAG2 10735
Affinity Capture-MS Homo sapiens
57 SLC7A1 6541
Two-hybrid Homo sapiens
58 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
59 BIRC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
60 CD40 958
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
61 C4orf32  
Affinity Capture-MS Homo sapiens
62 TRAF6 7189
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
63 SLC30A2  
Two-hybrid Homo sapiens
64 FANCD2  
Affinity Capture-MS Homo sapiens
65 HTRA2 27429
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
66 POLR2H 5437
Affinity Capture-MS Homo sapiens
67 KIAA1244  
Affinity Capture-MS Homo sapiens
68 UGGT1 56886
Affinity Capture-MS Homo sapiens
69 USP15 9958
Affinity Capture-MS Homo sapiens
70 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
71 TMEM128  
Two-hybrid Homo sapiens
72 SLC39A13 91252
Two-hybrid Homo sapiens
73 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
74 TNPO3 23534
Affinity Capture-MS Homo sapiens
75 MAP3K1 4214
Affinity Capture-Western Homo sapiens
76 ATXN10 25814
Affinity Capture-MS Homo sapiens
77 GBF1 8729
Affinity Capture-MS Homo sapiens
78 MAP3K8  
Affinity Capture-Western Homo sapiens
79 KIAA1524 57650
Affinity Capture-MS Homo sapiens
80 TRAF3 7187
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
81 NCDN 23154
Affinity Capture-MS Homo sapiens
82 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
83 ERP44 23071
Affinity Capture-MS Homo sapiens
84 HOOK3 84376
Affinity Capture-MS Homo sapiens
85 TMEM173  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
86 SAAL1 113174
Affinity Capture-MS Homo sapiens
87 XPO4 64328
Affinity Capture-MS Homo sapiens
88 XRCC6 2547
Reconstituted Complex Homo sapiens
89 COG8 84342
Affinity Capture-MS Homo sapiens
90 CMTM5  
Two-hybrid Homo sapiens
91 MTOR 2475
Affinity Capture-MS Homo sapiens
92 TRAF5  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
93 SLC30A7 148867
Affinity Capture-MS Homo sapiens
94 PIK3CA 5290
Affinity Capture-Western Homo sapiens
95 CD40LG 959
Affinity Capture-Western Homo sapiens
96 HSPA4 3308
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
97 EIF2B1 1967
Affinity Capture-MS Homo sapiens
98 MIP  
Two-hybrid Homo sapiens
99 DYM  
Affinity Capture-MS Homo sapiens
100 THADA 63892
Affinity Capture-MS Homo sapiens
101 CHUK 1147
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
102 HIP1R 9026
Affinity Capture-MS Homo sapiens
103 XRCC5 7520
Reconstituted Complex Homo sapiens
104 TANK 10010
Affinity Capture-Western Homo sapiens
105 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
106 MAL  
Two-hybrid Homo sapiens
107 TRAF2 7186
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
108 SGK1  
Affinity Capture-MS Homo sapiens
109 PLP1 5354
Two-hybrid Homo sapiens
110 COG1 9382
Affinity Capture-MS Homo sapiens
111 PEX19 5824
Affinity Capture-MS Homo sapiens
112 GPR180  
Affinity Capture-MS Homo sapiens
113 DDX3X 1654
Affinity Capture-MS Homo sapiens
114 RNF31 55072
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
115 CYB561A3 220002
Two-hybrid Homo sapiens
116 SLC39A7 7922
Affinity Capture-MS Homo sapiens
117 IKBKG 8517
Affinity Capture-Western Homo sapiens
118 MS4A1 931
Affinity Capture-Western Homo sapiens
119 DNAAF5 54919
Affinity Capture-MS Homo sapiens
120 THRAP3 9967
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
121 INTS2  
Affinity Capture-MS Homo sapiens
122 EBP  
Two-hybrid Homo sapiens
123 GEMIN4 50628
Affinity Capture-MS Homo sapiens
124 NUP98 4928
Affinity Capture-MS Homo sapiens
125 COG6 57511
Affinity Capture-MS Homo sapiens
126 STAG1  
Affinity Capture-MS Homo sapiens
127 TXN 7295
Affinity Capture-MS Homo sapiens
128 XPO5 57510
Affinity Capture-MS Homo sapiens
129 TTI2 80185
Affinity Capture-MS Homo sapiens
130 GEMIN6  
Affinity Capture-MS Homo sapiens
131 HDAC6 10013
Affinity Capture-MS Homo sapiens
132 EIF2B4 8890
Affinity Capture-MS Homo sapiens
133 SLC9A3R1 9368
Affinity Capture-MS Homo sapiens
134 IPO13 9670
Affinity Capture-MS Homo sapiens
135 NUP85 79902
Affinity Capture-MS Homo sapiens
136 IKBKB 3551
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
137 COG7 91949
Affinity Capture-MS Homo sapiens
138 ATP13A1 57130
Affinity Capture-MS Homo sapiens
139 TRAF1 7185
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
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