Gene description for XPO4
Gene name exportin 4
Gene symbol XPO4
Other names/aliases exp4
Species Homo sapiens
 Database cross references - XPO4
ExoCarta ExoCarta_64328
Vesiclepedia VP_64328
Entrez Gene 64328
HGNC 17796
MIM 611449
UniProt Q9C0E2  
 XPO4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for XPO4
Molecular Function
    nuclear export signal receptor activity GO:0005049 IBA
    nuclear export signal receptor activity GO:0005049 IDA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IDA
Biological Process
    protein export from nucleus GO:0006611 IBA
    protein export from nucleus GO:0006611 IDA
    positive regulation of protein export from nucleus GO:0046827 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear pore GO:0005643 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified XPO4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for XPO4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C5AR1  
Affinity Capture-MS Homo sapiens
2 UTRN 7402
Co-fractionation Homo sapiens
3 THOC2 57187
Co-fractionation Homo sapiens
4 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 FPR1  
Affinity Capture-MS Homo sapiens
6 GLCE 26035
Affinity Capture-MS Homo sapiens
7 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 C11orf87  
Affinity Capture-MS Homo sapiens
10 GPR34  
Affinity Capture-MS Homo sapiens
11 PTPMT1 114971
Affinity Capture-MS Homo sapiens
12 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MLST8 64223
Affinity Capture-MS Homo sapiens
14 SEMA4C 54910
Affinity Capture-MS Homo sapiens
15 UBQLN1 29979
Two-hybrid Homo sapiens
16 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TACSTD2 4070
Affinity Capture-MS Homo sapiens
18 ITFG3 83986
Affinity Capture-MS Homo sapiens
19 BRF2  
Affinity Capture-MS Homo sapiens
20 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 THOC1 9984
Co-fractionation Homo sapiens
22 GPR17 2840
Affinity Capture-MS Homo sapiens
23 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 GCGR  
Affinity Capture-MS Homo sapiens
26 C19orf38  
Affinity Capture-MS Homo sapiens
27 PLEKHM3 389072
Affinity Capture-MS Homo sapiens
28 P2RY8  
Affinity Capture-MS Homo sapiens
29 ILVBL 10994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 UBE2I 7329
Affinity Capture-MS Homo sapiens
31 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PTPRE 5791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 RAN 5901
Affinity Capture-MS Homo sapiens
34 S1PR1 1901
Affinity Capture-MS Homo sapiens
35 HMGB2 3148
Co-fractionation Homo sapiens
36 MLNR  
Affinity Capture-MS Homo sapiens
37 CD40 958
Affinity Capture-MS Homo sapiens
38 NTRK1 4914
Affinity Capture-MS Homo sapiens
39 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CYB5B 80777
Affinity Capture-MS Homo sapiens
41 F2RL1  
Affinity Capture-MS Homo sapiens
42 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 BTNL9  
Affinity Capture-MS Homo sapiens
44 ZHX1  
Co-fractionation Homo sapiens
45 FZD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 NPTN 27020
Affinity Capture-MS Homo sapiens
47 PTPRA 5786
Affinity Capture-MS Homo sapiens
48 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 P2RY2 5029
Affinity Capture-MS Homo sapiens
50 EGFR 1956
Affinity Capture-MS Homo sapiens
51 THOC5 8563
Co-fractionation Homo sapiens
52 OCIAD1 54940
Affinity Capture-MS Homo sapiens
53 NXF1 10482
Affinity Capture-RNA Homo sapiens
54 C3orf18  
Affinity Capture-MS Homo sapiens
55 GPR45  
Affinity Capture-MS Homo sapiens
56 MTOR 2475
Affinity Capture-MS Homo sapiens
57 PTPRN  
Affinity Capture-MS Homo sapiens
58 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 B3GAT3 26229
Affinity Capture-MS Homo sapiens
60 CACNG1  
Affinity Capture-MS Homo sapiens
61 TNFSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 THADA 63892
Affinity Capture-MS Homo sapiens
63 P2RY12 64805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 AVPR2  
Affinity Capture-MS Homo sapiens
65 GYPA  
Affinity Capture-MS Homo sapiens
66 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
67 FASN 2194
Positive Genetic Homo sapiens
68 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 OPALIN  
Affinity Capture-MS Homo sapiens
70 PHLDA3 23612
Affinity Capture-MS Homo sapiens
71 JTB 10899
Affinity Capture-MS Homo sapiens
72 RP2 6102
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CHRM4  
Affinity Capture-MS Homo sapiens
74 EFNB1 1947
Affinity Capture-MS Homo sapiens
75 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
76 LRRC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 HTR6  
Affinity Capture-MS Homo sapiens
79 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 SPN 6693
Affinity Capture-MS Homo sapiens
81 TPST2 8459
Affinity Capture-MS Homo sapiens
82 IPO13 9670
Co-fractionation Homo sapiens
83 EIF5A 1984
Reconstituted Complex Homo sapiens
84 KIR2DL4  
Affinity Capture-MS Homo sapiens
85 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 RANGAP1 5905
Affinity Capture-MS Homo sapiens
87 RANBP2 5903
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which XPO4 is involved
No pathways found





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