Gene description for ILVBL
Gene name ilvB (bacterial acetolactate synthase)-like
Gene symbol ILVBL
Other names/aliases 209L8
AHAS
ILV2H
Species Homo sapiens
 Database cross references - ILVBL
ExoCarta ExoCarta_10994
Vesiclepedia VP_10994
Entrez Gene 10994
HGNC 6041
MIM 605770
UniProt A1L0T0  
 ILVBL identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ILVBL
Molecular Function
    magnesium ion binding GO:0000287 IEA
    acetolactate synthase activity GO:0003984 IBA
    protein binding GO:0005515 IPI
    lyase activity GO:0016829 IEA
    thiamine pyrophosphate binding GO:0030976 IEA
    flavin adenine dinucleotide binding GO:0050660 IBA
Biological Process
    fatty acid alpha-oxidation GO:0001561 IDA
    isoleucine biosynthetic process GO:0009097 IBA
    L-valine biosynthetic process GO:0009099 IBA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    acetolactate synthase complex GO:0005948 IBA
    membrane GO:0016020 HDA
 Experiment description of studies that identified ILVBL in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ILVBL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COPG2 26958
Affinity Capture-MS Homo sapiens
2 HNRNPC 3183
Co-fractionation Homo sapiens
3 C5AR2  
Affinity Capture-MS Homo sapiens
4 UQCRFS1 7386
Co-fractionation Homo sapiens
5 MTCH1 23787
Co-fractionation Homo sapiens
6 UBL4A 8266
Affinity Capture-MS Homo sapiens
7 RAB1A 5861
Co-fractionation Homo sapiens
8 CBWD7  
Affinity Capture-MS Homo sapiens
9 C1orf27 54953
Affinity Capture-MS Homo sapiens
10 MDN1 23195
Affinity Capture-MS Homo sapiens
11 RPA2 6118
Proximity Label-MS Homo sapiens
12 ADRB2  
Affinity Capture-MS Homo sapiens
13 KIF20A 10112
Affinity Capture-MS Homo sapiens
14 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 INTS1 26173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PTPN1 5770
Affinity Capture-MS Homo sapiens
17 HOOK2  
Affinity Capture-MS Homo sapiens
18 COPA 1314
Affinity Capture-MS Homo sapiens
19 PI4KA 5297
Affinity Capture-MS Homo sapiens
20 ATP5L 10632
Co-fractionation Homo sapiens
21 AMHR2  
Affinity Capture-MS Homo sapiens
22 ATP1B1 481
Co-fractionation Homo sapiens
23 COG6 57511
Affinity Capture-MS Homo sapiens
24 NDUFS3 4722
Co-fractionation Homo sapiens
25 SKA1  
Affinity Capture-MS Homo sapiens
26 SDHB 6390
Co-fractionation Homo sapiens
27 COPB2 9276
Affinity Capture-MS Homo sapiens
28 PPP6R1 22870
Affinity Capture-MS Homo sapiens
29 INTS12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PPEF1  
Affinity Capture-MS Homo sapiens
31 PIGH  
Affinity Capture-MS Homo sapiens
32 TOM1 10043
Two-hybrid Homo sapiens
33 SLC7A6 9057
Affinity Capture-MS Homo sapiens
34 NCAPG2 54892
Affinity Capture-MS Homo sapiens
35 UFSP2 55325
Affinity Capture-MS Homo sapiens
36 MLST8 64223
Affinity Capture-MS Homo sapiens
37 PIGG  
Affinity Capture-MS Homo sapiens
38 FAF2 23197
Affinity Capture-MS Homo sapiens
39 UQCRQ 27089
Co-fractionation Homo sapiens
40 SLC25A3 5250
Co-fractionation Homo sapiens
41 GBA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ZW10 9183
Affinity Capture-MS Homo sapiens
43 HEATR1 55127
Affinity Capture-MS Homo sapiens
44 WDR45B 56270
Affinity Capture-MS Homo sapiens
45 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
46 RAB14 51552
Co-fractionation Homo sapiens
47 MSMO1 6307
Affinity Capture-MS Homo sapiens
48 RB1CC1 9821
Affinity Capture-MS Homo sapiens
49 PARK2  
Affinity Capture-MS Homo sapiens
50 PPP6R2 9701
Affinity Capture-MS Homo sapiens
51 COPE 11316
Affinity Capture-MS Homo sapiens
52 EIF2B5 8893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 FAM96B 51647
Affinity Capture-MS Homo sapiens
54 TBC1D32 221322
Proximity Label-MS Homo sapiens
55 TRIM21 6737
Affinity Capture-MS Homo sapiens
56 NTRK1 4914
Affinity Capture-MS Homo sapiens
57 TNPO3 23534
Affinity Capture-MS Homo sapiens
58 XPOT 11260
Affinity Capture-MS Homo sapiens
59 KIF11 3832
Affinity Capture-MS Homo sapiens
60 CYC1 1537
Co-fractionation Homo sapiens
61 TRIM66  
Affinity Capture-MS Homo sapiens
62 CEP76  
Two-hybrid Homo sapiens
63 COG5 10466
Affinity Capture-MS Homo sapiens
64 PICALM 8301
Co-fractionation Homo sapiens
65 VDAC2 7417
Co-fractionation Homo sapiens
66 COG4 25839
Affinity Capture-MS Homo sapiens
67 SLC33A1 9197
Affinity Capture-MS Homo sapiens
68 CNR2  
Affinity Capture-MS Homo sapiens
69 ZMYM4  
Affinity Capture-MS Homo sapiens
70 ATXN1 6310
Two-hybrid Homo sapiens
71 PICK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 ACAT1 38
Co-fractionation Homo sapiens
73 HSD17B14  
Co-fractionation Homo sapiens
74 SV2A 9900
Affinity Capture-MS Homo sapiens
75 CLN3 1201
Affinity Capture-MS Homo sapiens
76 RABGGTA 5875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 FANCD2  
Affinity Capture-MS Homo sapiens
78 CIAO1 9391
Affinity Capture-MS Homo sapiens
79 ECT2 1894
Two-hybrid Homo sapiens
80 SRSF1 6426
Co-fractionation Homo sapiens
81 OSBPL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 Nrip3  
Affinity Capture-MS Mus musculus
83 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 EGFR 1956
Affinity Capture-MS Homo sapiens
85 ARF6 382
Proximity Label-MS Homo sapiens
86 PTK2 5747
Proximity Label-MS Homo sapiens
87 URB2  
Affinity Capture-MS Homo sapiens
88 GHITM 27069
Affinity Capture-MS Homo sapiens
89 NCDN 23154
Affinity Capture-MS Homo sapiens
90 XPO6 23214
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 AURKB 9212
Affinity Capture-MS Homo sapiens
92 SAAL1 113174
Affinity Capture-MS Homo sapiens
93 MAPK6  
Affinity Capture-MS Homo sapiens
94 MYC  
Affinity Capture-MS Homo sapiens
95 RPA3 6119
Proximity Label-MS Homo sapiens
96 MTOR 2475
Affinity Capture-MS Homo sapiens
97 COG3 83548
Affinity Capture-MS Homo sapiens
98 NFKB1 4790
Affinity Capture-MS Homo sapiens
99 FBLIM1 54751
Affinity Capture-MS Homo sapiens
100 SLC12A6 9990
Affinity Capture-MS Homo sapiens
101 ILK 3611
Affinity Capture-MS Homo sapiens
102 CYFIP2 26999
Affinity Capture-MS Homo sapiens
103 THADA 63892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 TBC1D9B 23061
Affinity Capture-MS Homo sapiens
105 FLOT1 10211
Co-fractionation Homo sapiens
106 GEMIN4 50628
Affinity Capture-MS Homo sapiens
107 CLPP 8192
Proximity Label-MS Homo sapiens
108 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
109 NUP205 23165
Affinity Capture-MS Homo sapiens
110 FBXL6  
Affinity Capture-MS Homo sapiens
111 TTC27 55622
Affinity Capture-MS Homo sapiens
112 ATP1A3 478
Affinity Capture-MS Homo sapiens
113 OSTM1 28962
Affinity Capture-MS Homo sapiens
114 TPTE  
Affinity Capture-MS Homo sapiens
115 KIAA1429 25962
Affinity Capture-MS Homo sapiens
116 INTS2  
Affinity Capture-MS Homo sapiens
117 DDX58 23586
Affinity Capture-RNA Homo sapiens
118 XPO4 64328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
120 XPO5 57510
Affinity Capture-MS Homo sapiens
121 OSBPL3 26031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 MMS19 64210
Affinity Capture-MS Homo sapiens
123 Dctn3  
Affinity Capture-MS Mus musculus
124 SLC6A8 6535
Affinity Capture-MS Homo sapiens
125 BRD1 23774
Affinity Capture-MS Homo sapiens
126 XRCC6 2547
Two-hybrid Homo sapiens
127 C9orf72  
Affinity Capture-MS Homo sapiens
128 VDAC3 7419
Co-fractionation Homo sapiens
129 COG7 91949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 TBC1D8B 54885
Affinity Capture-MS Homo sapiens
131 DERL1 79139
Proximity Label-MS Homo sapiens
132 EVI5L  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ILVBL is involved
No pathways found





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