Gene description for MSMO1
Gene name methylsterol monooxygenase 1
Gene symbol MSMO1
Other names/aliases DESP4
ERG25
SC4MOL
Species Homo sapiens
 Database cross references - MSMO1
ExoCarta ExoCarta_6307
Entrez Gene 6307
HGNC 10545
MIM 607545
UniProt Q15800  
 MSMO1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for MSMO1
Molecular Function
    iron ion binding GO:0005506 IEA
    C-4 methylsterol oxidase activity GO:0000254 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    steroid metabolic process GO:0008202 TAS
    fatty acid metabolic process GO:0006631 TAS
    oxidation-reduction process GO:0055114 IEA
    fatty acid biosynthetic process GO:0006633 IEA
    cholesterol biosynthetic process GO:0006695 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum GO:0005783 TAS
    plasma membrane GO:0005886 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified MSMO1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MSMO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MSMO1 is involved
PathwayEvidenceSource
Cholesterol biosynthesis TAS Reactome





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