Gene description for GP5
Gene name glycoprotein V (platelet)
Gene symbol GP5
Other names/aliases CD42d
GPV
Species Homo sapiens
 Database cross references - GP5
ExoCarta ExoCarta_2814
Vesiclepedia VP_2814
Entrez Gene 2814
HGNC 4443
MIM 173511
UniProt P40197  
 GP5 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for GP5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    blood coagulation GO:0007596 IBA
    blood coagulation, intrinsic pathway GO:0007597 IPI
    blood coagulation, intrinsic pathway GO:0007597 NAS
    positive regulation of platelet activation GO:0010572 IDA
    positive regulation of platelet activation GO:0010572 NAS
    megakaryocyte development GO:0035855 ISO
    megakaryocyte development GO:0035855 NAS
    release of sequestered calcium ion into cytosol GO:0051209 IDA
    release of sequestered calcium ion into cytosol GO:0051209 NAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
    glycoprotein Ib-IX-V complex GO:1990779 IPI
    glycoprotein Ib-IX-V complex GO:1990779 NAS
 Experiment description of studies that identified GP5 in exosomes
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STARD3NL 83930
Affinity Capture-MS Homo sapiens
2 TOMM40 10452
Affinity Capture-MS Homo sapiens
3 KDELR3 11015
Affinity Capture-MS Homo sapiens
4 ACAD8 27034
Affinity Capture-MS Homo sapiens
5 CDS2 8760
Affinity Capture-MS Homo sapiens
6 SLC19A2 10560
Affinity Capture-MS Homo sapiens
7 CMTM6 54918
Affinity Capture-MS Homo sapiens
8 C4orf32  
Affinity Capture-MS Homo sapiens
9 DNAJC11 55735
Affinity Capture-MS Homo sapiens
10 CLN3 1201
Affinity Capture-MS Homo sapiens
11 DERL2 51009
Affinity Capture-MS Homo sapiens
12 RAB29 8934
Affinity Capture-MS Homo sapiens
13 TMC6 11322
Affinity Capture-MS Homo sapiens
14 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
15 DHCR24 1718
Affinity Capture-MS Homo sapiens
16 TTYH3 80727
Affinity Capture-MS Homo sapiens
17 ATP1A3 478
Affinity Capture-MS Homo sapiens
18 MSMO1 6307
Affinity Capture-MS Homo sapiens
19 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
20 CNNM2 54805
Affinity Capture-MS Homo sapiens
21 GP1BA 2811
Affinity Capture-Western Homo sapiens
22 RSAD1  
Affinity Capture-MS Homo sapiens
23 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
24 PGRMC2 10424
Affinity Capture-MS Homo sapiens
25 ATP12A 479
Affinity Capture-MS Homo sapiens
26 CNNM4 26504
Affinity Capture-MS Homo sapiens
27 RTN2 6253
Affinity Capture-MS Homo sapiens
28 CNPY3 10695
Affinity Capture-MS Homo sapiens
29 ADGRL3 23284
Affinity Capture-MS Homo sapiens
30 YIPF5 81555
Affinity Capture-MS Homo sapiens
31 GHITM 27069
Affinity Capture-MS Homo sapiens
32 RTN4 57142
Affinity Capture-MS Homo sapiens
33 SGPP1 81537
Affinity Capture-MS Homo sapiens
34 TOMM22 56993
Affinity Capture-MS Homo sapiens
35 TM9SF3 56889
Affinity Capture-MS Homo sapiens
36 ATP5G1  
Affinity Capture-MS Homo sapiens
37 SLC38A10 124565
Affinity Capture-MS Homo sapiens
38 UBAC2 337867
Affinity Capture-MS Homo sapiens
39 PTDSS2 81490
Affinity Capture-MS Homo sapiens
40 RAET1L  
Affinity Capture-MS Homo sapiens
41 LMF1 64788
Affinity Capture-MS Homo sapiens
42 GPRC5C 55890
Affinity Capture-MS Homo sapiens
43 SLC39A10 57181
Affinity Capture-MS Homo sapiens
44 IGSF3 3321
Affinity Capture-MS Homo sapiens
45 HMOX2 3163
Affinity Capture-MS Homo sapiens
46 ABHD3  
Affinity Capture-MS Homo sapiens
47 CNPY4 245812
Affinity Capture-MS Homo sapiens
48 COX18  
Affinity Capture-MS Homo sapiens
49 PRC1 9055
Affinity Capture-MS Homo sapiens
50 ADGRG6 57211
Affinity Capture-MS Homo sapiens
51 VMA21  
Affinity Capture-MS Homo sapiens
52 HSPD1 3329
Affinity Capture-MS Homo sapiens
53 LRRC40 55631
Affinity Capture-MS Homo sapiens
54 ATP2C1 27032
Affinity Capture-MS Homo sapiens
55 ZYG11B  
Affinity Capture-MS Homo sapiens
56 ATP2A3 489
Affinity Capture-MS Homo sapiens
57 TMEM70  
Affinity Capture-MS Homo sapiens
58 ARL10  
Affinity Capture-MS Homo sapiens
59 MGST3 4259
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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